Immunopathology of Celiac Disease

Erscheinungsjahr 2021
ISBN: 978-0-323-85311-8
Verlag: William Andrew Publishing

Buch, Englisch, 276 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 680 g

Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.

Zielgruppe

<p>Clinical gastroenterologist interested in the molecular aspects of celiac disease pathogenesis. Molecular biologists studying the development of inflammatory intestinal diseases. </p>

Autoren/Hrsg.

Weitere Mitwirkende

Castellanos, Ainara

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Omics of Celiac Disease Nora Fernandez-Jimenez 2. Implication of HLA genes in Celiac Disease Conchita Nuñez 3. Macrophages & Dendritic Cells in Celiac Disease Eduardo Arranz 4. Tight junction disruption in the development of celiac disease Amaia Jauregi-Miguel 5. Implication of epithelial cell dysfunction in CeD Celia Escudero-Hernández 6. Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response Fernando Chirdo 7. The biology of refractory celiac disease Govind Bhagat 8. Involvement of lncRNAs in Celiac disease pathogenesis Ainara Castellanos-Rubio

Über Autor(innen)

Castellanos, Ainara
Ainara Castellanos-Rubio obtained her PhD on Genetics from the University of the Basque Country (Spain) in 2010. During her PhD she studied gene expression alterations and genetic polymorphisms associated to Celiac Disease. She did a short term research stay in the University of Tampere (Finland) under the supervision of Dr Marku Makki and Dr Katri Lindfors where she used three dimensional cell cultures to describe different pathways involved in Celiac Disease development. On 2011 she joined the Laboratory of Dr Sankar Ghosh in Columbia University (NY, USA) where she carried out her postdoctoral studies. During her postdoctoral training, she studied the implication of long noncoding RNAs (lncRNAs) in the immune and inflammatory response and she discovered and functionally characterized a novel lncRNA involved in the susceptibility to Celiac Disease. Since 2017 she is an Ikerbasque Researcher in the University of the Basque Country, where she leads her own group. She is interested in the involvement of noncoding RNAs in the pathogenesis of autoimmune and inflammatory diseases and studies the influence of disease associated SNPs in the functional disturbance of these RNAs. More recently, she has become interested on the epitranscriptomic alterations involved in different aspects of RNA regulation and her group studies how SNPs and environmental factors can alter these epitranscriptomic signals influencing the inflammatory response that finally evolves in disease development.