Ionizing Radiation and the Immune Response - Part B

Erscheinungsjahr 2023
ISBN: 978-0-443-18432-1
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 610 g

Ionizing Radiation and the Immune Response, Part B, Volume 378 reviews the latest knowledge on the immune response induced by ionizing radiations. Specific chapters in this new release include NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flash therapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and much more.

Other sections cover the Role of Dendritic cells in radiation-induced immune response, the Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.

Autoren/Hrsg.

Weitere Mitwirkende

Mirjolet, Celine

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Preface

Lorenzo Galluzzi and Celine Mirjolet

1. Radio-induced lymphopenia in the era of anti-cancer immunotherapy: A clinical review

François de Kermenguy, Lydia Meziani, Michele Mondini, Céline Clémenson, Daphné Morel, Eric Deutsch and Charlotte Robert

2. Radiotherapy as a means to unlock NK cell immune response in solid tumors

Baude Jérémy, Limagne Emeric, Ladjohounlou Riad and Mirjolet Céline

3. The role of dendritic cells in radiation-induced immune responses

Aanchal Preet Kaur, Alejandro Alice, Marka R. Crittenden and Michael J. Gough

4. Immunomodulatory effects of targeted radionuclide therapy

Julie Constanzo, Yasmine Bouden, Lisa Godry, Pierre-Olivier Kotzky, Emmanuel Deshayes and J.-P. Pouget

5. Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy

Katiuska Passelli, David Repáraz and Fernanda Herrera

6. Radiation therapy-activated nanoparticle & immunotherapy: The next milestone in oncology?

Sébastien Penninckx, Juliette Thariat and Céline Mirjolet

7. Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy

Chang Su, Jonathon E. Himes and David G. Kirsch

8. Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy

Zi-Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu and Lin-Lin Bu

Über Autor(innen)

Mirjolet, Celine
Dr. Céline Mirjolet is a radiobiologist with in-depth knowledge of the impact of radiotherapy fractionation on the radiation-induced immune response and on the effectiveness of the radiotherapy and immunotherapy combination. She obtained a doctorate in radiobiology at the anti-cancer center of Nancy (France). She then moved to Brussels at the University of Belgium to study epigenetic mechanisms in transcriptional activity and cancer. For ten years, she has been working in the radiotherapy department of the Dijon cancer center in close collaboration with clinicians and physicists to develop translational research projects on the combination of immunotherapy and radiotherapy. She leads the preclinical research team in radiotherapy and radiobiology and her programs focus on the validation of preclinical concepts leading to the design of clinical trials.