Buch, Englisch, 178 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 295 g
Reihe: Milestones in Drug Therapy
Buch, Englisch, 178 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 295 g
Reihe: Milestones in Drug Therapy
ISBN: 978-3-0348-0779-1
Verlag: Springer
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.
This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
Weitere Infos & Material
Influenza Virus Virology.- Investigating the interaction between influenza and sialic acid – making and breaking the link.- Enzymology of Influenza Virus Sialidase.- Influenza Virus Sialidase and Structure-Based Drug Design.- The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors.- The Development of Non-carbohydrate-based Influenza Virus Sialidase Inhibitors.- Clinical Experience with Influenza Virus Sialidase Inhibitors.- Resistance Development to Influenza Virus Sialidase Inhibitors.
