Theranostic Iron-Oxide Based Nanoplatforms in Oncology

Synthesis, Metabolism, and Toxicity for Simultaneous Imaging and Therapy
Erscheinungsjahr 2024
ISBN: 978-981-99-6509-0
Verlag: Springer Nature Singapore

Buch, Englisch, 410 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 645 g

Reihe: Nanomedicine and Nanotoxicology

This book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Jabali, Ali

Savari, Mohammad-Nabil

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie Molekulare Chemische Nanostrukturen
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

Introduction.- Drug conjugation chemistry in iron oxide nanoparticles (IONPs).- Superparamagnetic iron oxide nanoparticle (SPION) Synthesis.- Properties of Iron oxide nanoparticles (IONPs).- Pharmacokinetics of IONPs.- Magnetic Nanoparticles in Stimuli-Responsive Drug Delivery Systems.- IONPs-based treatment methods.- Diagnosis.- Biosensing.- Bioassays Based on Magnetic Phenomena.- Cytotoxicity/toxicity.- Coatings.- Concluding remarks and future perspectives.

Über Autor(innen)

Mohammad-Nabil Savari completed his masters of medical nanotechnology at Tehran Medical Branch, IAU, Tehran, Iran. He had a master's semester in pathogenic microbiology at UT and received his bachelor's degree in biology from SBU. His research is currently focused on designing multifunctional nanoplatforms for multimodal treatment of glioblastoma multiforme. And he asks for cooperation from all researchers in this field.

Dr. Ali Jabali, a specialist in medical nanotechnology, obtained his doctorate at Shahid Beheshti University, Iran, and completed a post-doctoral course at the University of Zaragoza, Spain. Currently, he is a member of the academic staff of Tehran Azad University of Medical Sciences, Iran, and he is teaching and researching in the field of nanotechnology. Designing new and engineered nanoparticles is one of his goals, and applying smart nanoparticles is one of his dreams. He is currently working on various national and international projects, and all researchers are invited to cooperate.