Jankowski / Wandtke Interleukin-27: Biological Properties and Clinical Application

1. Auflage 2016
ISBN: 978-3-319-39664-4
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 86 Seiten, eBook

Reihe: SpringerBriefs in Immunology

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

Zielgruppe

Research

Autoren/Hrsg.

Jankowski, Marek

Wandtke, Tomasz

Weitere Mitwirkende

Jakubowska, Marta

Inhaltsverzeichnis

IL-27: Structure, Regulation and Variability.- IL-27: A Key Player in Immune Regulation.- IL-27 in Health and Disease.