Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy

2012
ISBN: 978-3-642-43795-3
Verlag: Springer

Buch, Englisch, 212 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 353 g

Reihe: Springer Theses

In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.

Zielgruppe

Research

Autoren/Hrsg.

J. N. Junk, Matthias

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Naturwissenschaften Chemie Organische Chemie Polymerchemie
• Naturwissenschaften Chemie Analytische Chemie Magnetresonanz

Inhaltsverzeichnis

Electron Paramagnetic Resonance Theory.- The Functional Structure of Human Serum Albumin.- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties.- Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels.- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents.- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers.