Human and Animal Filariases

Landscape, Challenges, and Control
1. Auflage 2022
ISBN: 978-3-527-34659-2
Verlag: WILEY-VCH

Buch, Englisch, 656 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 1191 g

Reihe: Drug discovery in infectious diseases

Human and Animal Filariases

The rational approach to controlling human and animal diseases caused by nematodes

Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs.

Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination.

Human and Animal Filariases readers will find: - A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery
- Practical information on assay development, target validation, and required drug product profiles
- Insights from global experts from leading academic institutions as well as from pharma and healthcare companies

Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.

Autoren/Hrsg.

Kaminsky, Ronald

Geary, Timothy G.

Weitere Mitwirkende

Selzer, Paul M.

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Parasitologie
• Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Bakteriologie, Virologie, Parasitologie

Inhaltsverzeichnis

Introduction
Filariae as Organisms
Human Filarial Infections: Reflections on the Current Understanding of Their Importance, Pathobiology and Management
Canine Filariasis (Heartworm) - Disease and Current Gaps
Veterinary Diagnosis of Filarial Infection
Antifilarial Chemotherapy: Current Options for Humans
Antifilarial Chemotherapy: Current Options in Veterinary Medicine
Heartworm Disease - Intervention and Industry Perspective
Current Antifilarial Drugs - Mechanisms of Action
Drug Resistance in Filariae
Elimination and Eradication of Human Filariases
Global Economics of Heartworm Disease
Product Profiles for New Drugs Against Human and Animal Filariasis
Discovery and Development of New Antifilarial Drugs (in vitro Assays)
In vivo Models for the Discovery of New Antifilarial Drugs
In vivo Assays - Discovery and Development of New Antifilarial Drugs in Companion Animals
The Antifilarial Drug Pipeline
The Host-Helminth Interface as a Rich Resource for Novel Drug Targets
Functional Genomics of Filariae
Development of a Vaccine Against Onchocerca volvulus
Vector Control Approaches to Interrupt Transmission of Human Filarial Parasites
Vector Control Approaches for Canine Filariasis
Wolbachia Endosymbionts as Treatment Targets for Filarial Diseases

Über Autor(innen)

Ronald Kaminsky is a widely-recognized expert in the discovery and development of antiparasitic drugs with an extensive history of research on trypanosomiasis in Africa and Switzerland. He served as Head of Parasitology Research at Novartis Animal Health from 2006-2014 and is currently a consultant for antiparasitic drug discovery in the animal health sector. Dr. Kaminsky has authored more than 100 publications and received numerous awards during his career in academia and industry.
 
Timothy Geary is the former Director of the Institute of Parasitology at McGill University. Prior to joining the faculty at McGill in 2005, he spent 20 years in parasitology research in the animal health industry (Upjohn/Pharmacia/Pfizer). The author of more than 225 publications in the pharmacology of antiparasitic drugs and drug discovery and development, Prof. Geary serves as a consultant to many animal health companies and other organizations.
 
Paul M. Selzer studied Biology, Parasitology, and Biochemistry at the University of Tübingen, Germany, where he also received his PhD in Biochemistry. During his career he has worked as a researcher and scientific manager for several pharmaceutical companies, and is currently holding a management position in antiparasitic drug discovery at Boehringer Ingelheim Animal Health. He is also a visiting professor at the Interfaculty Institute of Biochemistry of the University of Tübingen, DE and an honorary professor of the Department of Infection, Immunity, and Inflammation at the University of Glasgow, UK.