Kim Advanced Pharmaceutics

Physicochemical Principles
1. Auflage 2004
ISBN: 978-1-135-49967-9
Verlag: CRC Press
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 512 Seiten

Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms.

Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used. The book provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.

Zielgruppe

Pharmaceutical scientists and researchers, pharmaceutical process engineers, pharmacologists, FDA regulatory personnel, and students

Autoren/Hrsg.

Kim, Cherng-ju

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

THERMODYNAMICS
Ideal Gases
Real Gases
Thermodynamics
Free Energy

IONIC EQUILIBRIUM
Strong Acids and Bases
Monoprotic Weak Acids and Weak Bases
Polyprotic Weak Acids and Weak Bases
Sparingly Soluble Salts

SOLUTIONS AND DISTRIBUTION
Solutions of Solids and Non-volatile Liquids in Liquids
Solutions of Volatile Liquids in Liquids
Solutions of Gases in Liquids (Henry's Law)
Colligative Properties
Distribution Law (Partition Coefficient)

SURFACE CHEMISTRY AND COLLOIDS
Adsorption from Solutions
Liquid-Liquid Systems (Emulsions)
Solid-Liquid Systems (Suspensions)

KINETICS
Pathways of Drug Degradation
Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions
Irreversible Reactions
Determination of the Order of Reaction and Its Rate Constant
Other Irreversible Reactions
Reversible Reactions
Reversible and Series Reactions (Eigenvalue Method)
Use of Laplace Transform for Differential Rate Equations
Enzyme-Substrate Reactions
Acid-Base Catalyzed Degradation Kinetics
Oxidation (Free Radical Reaction)
Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes
Temperature Effects on Reaction Rate Constants

DIFFUSION
Diffusion
Diffusion Through a Membrane
Diffusion in a Monolithic Matrix
Diffusion in a Membrane-Matrix System
Diffusion During the Swelling of Matrix
Diffusion in a Matrix Erosion/Degradation
Diffusion in a Matrix Swelling/Erosion
Diffusion with Chemical Reaction in a Membrane
Surface Area and Concentration Gradient Systems
Osmotically Controlled Systems

POLYMER SCIENCE
Classification of Polymers
Molecular Weight and Molecular Weight Distribution of Polymers
Characterization of Polymers
Polymer Synthesis
Natural Polymers and Their Modification
INDEX