Klein Advances in Cancer Research

1. Auflage 2001
ISBN: 978-0-08-048825-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 81, 212 Seiten, Web PDF

Reihe: Advances in Cancer Research

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.

Autoren/Hrsg.

Klein, George

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributors to Volume 81;8
4;Chapter 1. A Decade of Progress in Allogeneic Hematopoietic Cell Transplantation: 1990–2000;9
4.1;I. Introduction ;10
4.2;II. Prophylaxis Against Graft-Versus-Host Disease;10
4.3;III. Source of Allogeneic Hematopoietic Cells;14
4.4;IV. Matched Unrelated Donor Transplantation;16
4.5;V. Transplantation of Umbilical Cord Blood Cells;19
4.6;VI. Transplantation from Haploidentical Donors;21
4.7;VII. Immunotherapy Following Relapse;23
4.8;VIII. Allogeneic Transplantation Using Nonmyeloablative Regimens;24
4.9;IX. Complications of Allogeneic Hematopoietic Cell Transplantation;27
4.10;X. Advances in Allogeneic Hematopoietic Cell Transplantation for Specific Diseases;33
4.11;XI. Conclusions and Future Directions;56
4.12;References ;56
5;Chapter 2. A Role For Secondary V(D)J Recombination in Oncogenic Chromosomal Translocations?;69
5.1;I. Introduction ;70
5.2;II. V(D)J Rearrangement;71
5.3;III. Illicit V(D)J Rearrangement Mediated by Cryptic Rss or Rss-Like Motifs;80
5.4;IV. The Germinal Center;81
5.5;V. Chromosomal Translocations in GC-Like Lymphomas;86
5.6;VI. Research;91
5.7;VII. Conclusions;94
5.8;References ;95
6;Chapter 3. Recombinant Immunotoxins in Targeted Cancer Cell Therapy;101
6.1;I. Introduction ;102
6.2;II. Design of Recombinant Immunotoxins;106
6.3;III. Construction and Production of Recombinant Immunotoxins;112
6.4;IV. Preclinical Development of Recombinant Immunotoxins;113
6.5;V. Application of Recombinant Immunotoxins;115
6.6;VI. Other Applications of Recombinant Antibody Fragments;119
6.7;VII. Challenges and Future Directions of Recombinant Immunotoxins;123
6.8;References ;127
7;Chapter 4. Human Herpesvirus-8 and Kaposi's Sarcoma: Relationship with the Multistep Concept of Tumorigenesis;133
7.1;I. Clinical Presentation of KS;134
7.2;II. Histology of KS and Nature of KS Spindle Cells;135
7.3;III. HHV-8 and KS;136
7.4;Iv. Conclusion ;156
7.5;References ;158
8;Chapter 5. Reactivation and Role of HHV-8 in Kaposi's Sarcoma Initiation;169
8.1;I. Kaposi S Sarcoma ;170
8.2;II. Risk Factors Associated with KS Development;172
8.3;III. Histology of KS and Origin of Spindle Cells;174
8.4;IV. HHV-8 Infection in KS Lesions;177
8.5;V. KS Initiation: Role of IC in KS Histogenesis and HHV-8 Infection;178
8.6;VI. Lack of Control of Reactivated HHV-8;189
8.7;VII. KS Progression: Oncogenes, Oncosuppressor Genes, HHV-8 Latency Genes, and the HIV-1 Tat Protein;192
8.8;VIII. Concluding Remarks;195
8.9;References ;196
9;Index;209