Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

The Shape of Organic Synthesis to Come
1. Auflage 2019
ISBN: 978-981-13-6246-0
Verlag: Springer Nature Singapore

Buch, Englisch, 355 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 662 g

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

Zielgruppe

Research

Autoren/Hrsg.

Kobayashi, Yuichi

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

1. Microbial Fraction Library: A Screening Source for Drug Discovery.- 2. Efficient Total Synthesis of Omura Natural Products.- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol.- 4. Synthetic Approaches on the Pluramycin-class Antibiotics.- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II.- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis.- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications.- 8. Total Synthesis of Ingenol.- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids.- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid.- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds.- 12. Exploring bioactive marine natural products and identification of their molecular targets.- 13. Target protein chemical modification.- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes

Über Autor(innen)

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology.