Buch, Englisch, Band 221, 249 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 613 g
Reihe: Topics in Current Chemistry
Magnetic Resonance Imaging
Buch, Englisch, Band 221, 249 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 613 g
Reihe: Topics in Current Chemistry
ISBN: 978-3-540-42247-1
Verlag: Springer Berlin Heidelberg
Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Organische Chemie Supramolekularchemie
- Naturwissenschaften Chemie Physikalische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Magnetresonanztomographie, Computertomographie (MRT, CT)
- Naturwissenschaften Chemie Analytische Chemie Magnetresonanz
Weitere Infos & Material
Extracellular MRI Contrast Agents Based on Gadolinium.- Structures of MRI Contrast Agents in Solution.- Relaxivity of MRI Contrast Agents.- Kinetic Stabilities of Gadolinium(III) Chelates Used as MRI Contrast Agents.- New Classes of MRI Contrast Agents.- Non-Gadolinium-Based MRI Contrast Agents.- Blood-Pool MRI Contrast Agents: Properties and Characterization.
