Langel / Cravatt / Graslund Introduction to Peptides and Proteins

1. Auflage 2011
ISBN: 978-1-4398-8204-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 420 Seiten

Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.

Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into –

- Basic peptide and protein science from assembly through degradation

- Traditional and emerging research methods including those used in bioinformatics and proteomics

- New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects

After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.

Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer’s, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.

No longer just the domain of biologists, many key advances in protein research started in physics labs and have involved contributions from a host of fields including statistics, drug development, genetics, and chemical spectroscopy. Introduction to Peptides and Proteins provides researchers across these fields with the thorough foundation needed to explore all the potential that protein research offers.

Zielgruppe

Students and researchers in biochemistry, biotechnology, molecular and cell biology, pharmacology and organic chemists

Autoren/Hrsg.

Langel, Ulo

Cravatt, Benjamin F.

Graslund, Astrid

von Heijne, N.G.H.

Zorko, Matjaz

Land, Tiit

Niessen, Sherry

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Preface
Further Reading
Biography

Introduction to Part 1; Matjaž Zorko
From Building Block to 3-D Structure
Amino Acids; Matjaž Zorko
Noncovalent Interactions; Matjaž Zorko
Structural Organization of Proteins; Matjaž Zorko

Protein Biosynthesis and Posttranslational Modifications
The Biosynthesis of Proteins; Matjaž Zorko
Posttranslational Modifications; Matjaž Zorko

Folding of Proteins
Protein Folding; Matjaž Zorko
Intracellular Sorting of Proteins; Gunnar von Heijne

Protein Degradation
Protein Turnover; Matjaž Zorko

Introduction to Part II; Astrid Gräslund
Purification and Characterization of Proteins; Matjaž Zorko
Crystallography and X-Ray Diffraction Astrid Gräslund
Optical Spectroscopy; Astrid Gräslund
Nuclear Magnetic Resonance (NMR); Astrid Gräslund
Methods to Follow Protein Folding; Astrid Gräslund
Mass Spectrometry; Astrid Gräslund
Chemical Synthesis of Peptides and Proteins; Ülo Langel

Introduction to Part III; Tiit Land
Protein Engineering and Gene Silencing; Ülo Langel
Protein–Ligand Interactions; Ülo Langel
Sequence Analysis and Function Prediction; Tiit Land
Protein Structure Prediction; Tiit Land
Proteomics; Sherry Niessen and Benjamin F. Cravatt

Introduction to Part IV; Ülo Langel
Enzymes; Matjaž Zorko
Nucleic Acid–Binding Proteins; Ülo Langel
Cell Surface Receptors and Signaling; Ülo Langel
Membrane Proteins; Gunnar von Heijne
Antibodies; Ülo Langel
Fibrous Proteins; Ülo Langel
Selected Classes of Bioactive Peptides; Ülo Langel
Introduction to Part V; Ülo Langel and Astrid Gräslund
Misfolding-Based Diseases; Astrid Gräslund
Miscleavage-Based Diseases; Astrid Gräslund
Missequence-Based Diseases; Astrid Gräslund
Peptides and Proteins as Drugs; Ülo Langel