Essentials of Stem Cell Biology

4th Auflage
ISBN: 978-0-443-15420-1
Verlag: Elsevier Science

Buch, Englisch, 600 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

Autoren/Hrsg.

Lanza, Robert

Atala, Anthony

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Virologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie

Inhaltsverzeichnis

PART ONE: INTRODUCTION TO STEM CELLS
1. Why Stem Cell Research? Advances in the Field
2. ‘Stemness’: Definitions, Criteria, and Standards
3. Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges
4. Embryonic Stem Cells in Perspective
5. The Development of Epithelial Stem Cell Concepts

PART TWO: BASIC BIOLOGY/MECHANISMS
6. Stem Cell Niches
7. Mechanisms of Stem Cell Self-Renewal
8. Cell Cycle Regulators in Stem Cells
9. How Cells Change Their Phenotype

PART THREE: TISSUE AND ORGAN DEVELOPMENT
10. Differentiation in Early Development
11. Stem Cells Derived from Amniotic Fluid
12. Stem and Progenitor Cells Isolated from Cord Blood
13. The Nervous System
14. Sensory Epithelium of the Eye and Ear
15. Epithelial Skin Stem Cells
16. Hematopoietic Stem Cells
17. Peripheral Blood Stem Cells
18. Multipotent Adult Progenitor Cells
19. Mesenchymal Stem Cells
20. Skeletal Muscle Stem Cells
21. Stem Cells and the Regenerating Heart
22. Cell Lineages and Stem Cells in the Embryonic Kidney
23. Adult Liver Stem Cells
24. Pancreatic Stem Cells
25. Stem Cells in the Gastrointestinal Tract

PART FOUR: METHODS
26. Induced Pluripotent Stem Cells
27. Embryonic Stem Cells: Derivation and Properties
28. Isolation and Maintenance of Murine Embryonic Stem Cells
29. Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives
30. Derivation and Differentiation of Human Embryonic Germ Cells

PART FIVE: APPLICATIONS
32. Neural Stem Cells - Therapeutic Applications in Neurodegenerative Diseases
33. Adult Progenitor Cells as a Potential Treatment for Diabetes
34. Burns and Skin Ulcers
35. Stem Cells and Heart Disease
36. Stem Cells for the Treatment of Muscular Dystrophy
37. Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells
38. Orthopedic Applications of Stem Cells
39. Embryonic Stem Cells in Tissue Engineering

PART SIX: REGULATION AND ETHICS
40. Ethical Considerations
41. Overview of the FDA Regulatory Process

Über Autor(innen)

Atala, Anthony
Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute's Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.