Systems Biology of Apoptosis

2013
ISBN: 978-1-4899-9312-0
Verlag: Springer

Buch, Englisch, 204 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 3343 g

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

Zielgruppe

Research

Autoren/Hrsg.

Lavrik, Inna N.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

Preface.- Modeling formalisms in systems biology of apoptosis.- Systems biology of death receptor-induced apoptosis.- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis.- Systems Biology of the Mitochondrial Apoptosis Pathway.- Systems biology of cell death in hepatocytes.- Understanding different types of cell death using Systems Biology.- Modeling Single Cells in Systems Biology.- Cytokine-cytokine crosstalk and cell-death decisions.- Genetic and genomic dissection of apoptosis signaling.- Index.