Biomedical Applications of Extracellular Vesicles

1. Auflage 2023
ISBN: 978-3-527-35212-8
Verlag: Wiley-VCH GmbH

Buch, Englisch, 208 Seiten, Format (B × H): 171 mm x 246 mm, Gewicht: 558 g

Biomedical Applications of Extracellular Vesicles

Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine

Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more.

The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented.

Sample topics covered in Biomedical Applications of Extracellular Vesicles include: - Biogenesis of various EVs
- Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs
- EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases
- Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method
- Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs
- Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs

Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Autoren/Hrsg.

Li, Zhenhua

Liang, Xing-Jie

Cheng, Ke

Liang, Xingjie

Bai, Chunli

Liu, Minghua

Weitere Mitwirkende

Bai, Chunli

Liu, Minghua

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1. Extracellular vesicles and their biomedical applications: An Overview
2. Biogenesis and identification of extracellular vesicles
3. Therapeutic potential of extracellular vesicles from different cell sources
4. Biomedical applications of extracellular vesicles in treatment of disease
5. Applications of engineered extracellular vesicles
6. Current technology for extracellular vesicles production, isolation and quality control
7. Prospects and limitations of clinical application of extracellular vesicles
8. Conclusion and future perspectives

Über Autor(innen)

Dr. Zhenhua Li is the Professor of Southern Medical University, China and his Ph.D. degrees are from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. His research focus on the design of biomimetic materials for cancer therapy and regenerative medicine. Prof. Zhenhua Li has authored >90 publications including Nature Nanotechnology, Nature Biomedical Engineering, Science Advances, Nature Communications. His works have been cited over 4800 times so far and H-index is 42. He is a guest editor of Frontiers in Cardiovascular Medicine and Chemistry, and an editorial board member of Chinese Chemical Letters and Exploration.
 
Dr. Xing-Jie Liang got his Ph.D at National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences. He finished his postdoc with Dr. Michael M. Gottesman (Deputy Director of NIH, USA and Academician member of US national academy of sciences) for 5 years at Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Then, he worked as a Research Fellow at Surgical Neurology Branch, NINDS (National Institute of Neurological Diseases and Strokes, NIH) for 2 years. In 2007, he was an Assistant professor at Department of Radiology, School of Medicine, Howard University. Dr. Liang currently is deputy director of Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences and Lab Chief of Laboratory of Controllable Nanopharmaceuticals, National Center for Nanoscience and Technology of China. He is also leading a group on nanopharmaceuticals at the CAS Center for Excellence in Nanoscience and Chief Lecture Professor of Nanobiology at University of Chinese Academy of Sciences.
 
Ke Cheng is Professor in the Department of Molecular Biomedical Sciences at the College of Veterinary Medicine and Professor in the UNC/NCSU joint Department of Biomedical Engineering. He is also an adjunct professor at the UNC Eshelman School of Pharmacy and UNC School of Medicine. His research focuses on the development of novel nano theranostic agents for regenerative medicine as well as bioengineering approaches to augment stem cell engraftment and potency.