Lifshitz / Laskin Principles of Mass Spectrometry Applied to Biomolecules

1. Auflage 2006
ISBN: 978-0-470-05041-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 704 Seiten, E-Book

Reihe: Wiley-Interscience Series on Mass Spectrometry

An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.

Autoren/Hrsg.

Lifshitz, Chava

Laskin, Julia

Inhaltsverzeichnis

Contributors.
Preface.
STRUCTURES AND DYNAMICS OF GAS-PHASE BIOMOLECULES.
1. Spectroscopy of neutral Peptides in the Gas Phase-Structure,Reactivity, Microsolvation, Molecular Recognition (M.Gerhards).
2. Probing the Electronic Structure of Fe-S Clusters Using AnoinPhotoelectron Spectroscopy: Ubiquitous Electron Transfer Centers inMetalloproteins (X. Yang, et al.).
3. Ion/Molecule Reactions and H/D Exchange for StructuralCharacterization of Biomolecules (M. Green & C. Lebrilla).
4. Understanding Protein Interactions and their Representationin the Gas Phase of the Mass Spectrometer (F. Sobott & C.Robinson).
5. Protein Structure and Folding in the Gas Phase: Ubiquitin andCytochrome c (K. Breuker).
6. Dyunamical Simulations of Photoionization of Small BiologicalMolecules (D. Shemesh & R. Gerber).
7. IVR and Ergodicity of Dissociation of Bio-Molecules (C.Lifshitz).
PART II: ACTIVATION, DISSOCIATION AND REACTIVITY.
8. Mechanisms of Peptide Fragmentation (V. Wysocki, et al.).
9. Peptide Radical Cations (A. Hopkinson & K. Siu).
10. Photodissociation of Biomolecule Ions: Progress,Possibilities, and the Perspectives Coming From Small-Ion Models(R. Dunbar).
11. Chemical Dynamics Simulations of EnergyTransfer andUnimolecular Decomposition in Collision-Induced Dissociation (CID)and Surface-Induced Dissociation (SID) (A. Rahaman, et al.).
12. Ion Soft Landing: Instrumentation, Phenomena andApplications (B. Gologan, et al.).
13. Electron Capture Dissociation and Other Ion-electronFragmentation Reactions (R. Zubarev).
14. Biomolecule Ion/Ion Reactions (S. McLuckey).
PART III: THERMOCHEMISTRY AND ENERGETICS.
15. Thermochemistry Studies of Biomolecules (C.Wesdemiotis).
16. Energy and Entropy Effects in the Gas Phase Dissociation ofPeptides and Proteins (J. Laskin).
Index.

Über Autor(innen)

JULIA LASKIN, PHD, is a Senior Research Scientist in theFundamental Sciences Division at the Pacific Northwest NationalLaboratory in Richland, Washington.
The late CHAVA LIFSHITZ, PHD, was an Archie and MarjorieSherman Professor of Chemistry in the Department of PhysicalChemistry at The Hebrew University in Jerusalem, Israel. She wasalso on the editorial boards of Mass Spectrometry Reviews and theInternational Journal of Mass Spectrometry.