Ligler / Taitt Optical Biosensors

Today and Tomorrow
2. Auflage 2011
ISBN: 978-0-08-056494-4
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 712 Seiten

Optical Biosensors, 2ed describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field.
* Comprehensive analysis and review of the underlying principles by optical biosensors
* Updates and informs on all the latest developments and hot topic areas
* Evaluates current methods showing the advantages and disadvantages of various systems involved

Autoren/Hrsg.

Ligler, Frances S.

Taitt, Chris Rowe

Inhaltsverzeichnis

1;Cover;1
2;Table of Contents;8
3;Preface;10
4;List of Contributors;12
5;PART I OPTICAL BIOSENSORS: TODAY;22
5.1;Chapter 1 Optrode-based fiber optic biosensors (bio-optrode);24
5.1.1;1.1. Principle of operation;25
5.1.2;1.2. History;55
5.1.3;1.3. State of the art for bio-optrodes;56
5.1.4;1.4. Advantages and limitations of bio-optrode technology;86
5.1.5;1.5. Potential for improving performance or expanding current capabilities;87
5.1.6;References;94
5.2;Chapter 2 Evanescent wave fiber optic biosensors;104
5.2.1;2.1. Technical concept;104
5.2.2;2.2. History;127
5.2.3;2.3. State of the art;128
5.2.4;2.4. Advantages and limitations;146
5.2.5;2.5. Future of evanescent fiber optic biosensors;150
5.2.6;Acknowledgements;153
5.2.7;References;153
5.3;Chapter 3 Planar waveguides for fluorescence biosensors;160
5.3.1;3.1. Technical concept;161
5.3.2;3.2. History;175
5.3.3;3.3. State of the art;179
5.3.4;3.4. Advantages and limitations for use in optical biosensing;190
5.3.5;3.5. Potential for improving performance or expanding current capabilities;191
5.3.6;Acknowledgements;197
5.3.7;References;197
5.4;Chapter 4 Surface plasmon resonance biosensors;206
5.4.1;4.1. Technical concept;206
5.4.2;4.2. History;231
5.4.3;4.3. State of the art;232
5.4.4;4.4. Advantages and limitations of SPR biosensors;254
5.4.5;4.5. Potential for expanding current capabilities;256
5.4.6;References;258
5.5;Chapter 5 Flow immunosensors;264
5.5.1;5.1. Principles of operation;265
5.5.2;5.2. History of the displacement immunosensor;270
5.5.3;5.3. Applications/implementation of the displacement immunosensor;278
5.5.4;5.4. History of the kinetic exclusion sensor;285
5.5.5;5.5. Advantages and limitations;295
5.5.6;5.6. Future potential;299
5.5.7;Acknowledgments;302
5.5.8;References;302
5.6;Chapter 6 Fluorescence lifetime biosensing: Entering the mainstream;308
5.6.1;6.1. Technical concept;308
5.6.2;6.2. History;319
5.6.3;6.3. State of the art;323
5.6.4;6.4. Advantages and limitations for use in optical biosensing;329
5.6.5;6.5. Potential for improving performance or expanding current capabilities;332
5.6.6;References;335
5.7;Chapter 7 Electrochemiluminescence;338
5.7.1;7.1. Principles of operation;338
5.7.2;7.2. History;352
5.7.3;7.3. State of the art;361
5.7.4;7.4. Advantages and limitations;375
5.7.5;7.5. Potential for expanding current capabilities;376
5.7.6;References;391
5.8;Chapter 8 Plasmonic SERS molecular sentinels: A new biosensing approach;406
5.8.1;8.1. Technical concept;407
5.8.2;8.2. History;410
5.8.3;8.3. State of the art;414
5.8.4;8.4. Advantages and limitations for use in optical biosensing;416
5.8.5;8.5. Potential for improving performance or expanding current capabilities;417
5.8.6;Acknowledgments;419
5.8.7;References;419
6;PART II OPTICAL BIOSENSORS: TOMORROW;422
6.1;Chapter 9 Cavity ring-down biosensing;424
6.1.1;9.1. Technical concept;424
6.1.2;9.2. History;431
6.1.3;9.3. State of the art;434
6.1.4;9.4. Potential for improving performance or expanding current capabilities;437
6.1.5;References;438
6.2;Chapter 10 Cantilever biosensors;440
6.2.1;10.1. Technical concept;440
6.2.2;10.2. History;454
6.2.3;10.3. State of the art;455
6.2.4;10.4. Advantages and limitations for use in optical biosensing;467
6.2.5;10.5. Potential for improving performance or expanding current capabilities;469
6.2.6;Acknowledgements;470
6.2.7;References;470
6.3;Chapter 11 Protein microarray technologies: An array of applications;474
6.3.1;11.1. Technical concept;475
6.3.2;11.2. Historical background;480
6.3.3;11.3. Applications for protein microarrays;481
6.3.4;11.4. Advantages and limitations of protein microarrays;485
6.3.5;References;486
6.4;Chapter 12 Single-domain antibodies: Rugged recognition elements for tomorrow’s biosensors;490
6.4.1;12.1. Technical concept;491
6.4.2;12.2. History;493
6.4.3;12.3. State of the art;500
6.4.4;12.4. Advantages and limitations for use in optical biosensing;508
6.4.5;12.5. Potential for improving performance or expanding current capabilities;509
6.4.6;Acknowledgements;510
6.4.7;References;510
6.5;Chapter 13 Nucleic acids for reagentless biosensors;514
6.5.1;13.1. The concept of a reagentless biosensor;515
6.5.2;13.2. History – in vitro selection;516
6.5.3;13.3. State of the art;522
6.5.4;13.4. Advantages and limitations;546
6.5.5;13.5. Potential for improving performance;548
6.5.6;References;556
6.6;Chapter 14 Imprinted polymers and their application in optical sensors;564
6.6.1;14.1. Molecular imprinting: technical concepts;565
6.6.2;14.2. Development of MIP-based optical sensors: history and state of the art;581
6.6.3;14.3. Market potential of MIP sensors and future prospects;595
6.6.4;14.4. New developments;596
6.6.5;References;598
6.7;Chapter 15 Nanoparticles for biosensors;604
6.7.1;15.1. Technical concepts;605
6.7.2;15.2. State of the art;613
6.7.3;15.3. Advantages and disadvantages;633
6.7.4;15.4. Future perspectives;635
6.7.5;References;637
6.8;Chapter 16 Fluorescence-based intracellular sensing;644
6.8.1;16.1. Technical concepts;644
6.8.2;16.2. History;650
6.8.3;16.3. State of the art;655
6.8.4;16.4. Advantages and limitations for use in optical biosensing;668
6.8.5;16.5. Potential for improving performance or expanding current capabilities;670
6.8.6;Acknowledgements;673
6.8.7;References;673
6.9;Chapter 17 Microfluidics;680
6.9.1;17.1. Technical concept;680
6.9.2;17.2. History;685
6.9.3;17.3. State of the art;686
6.9.4;17.4. Advantages and limitations for use in optical biosensing;698
6.9.5;17.5. Potential for improving performance or expanding current capabilities;699
6.9.6;References;700
7;Index;704
8;Color Plates;710