Studies of Narcosis

Charles Ernest Overton
Softcover Nachdruck of the original 1. Auflage 1991
ISBN: 978-94-010-5371-6
Verlag: Springer Netherlands

Buch, Englisch, 203 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 341 g

Charles Ernest Overton's 1901 monograph Studien aber die Narkose has become a scientific classic in a number of different fields. This book represents the first English translation, and in fact the first translation into any other language, of the original German work. In addition to· the edited translation, this volume contains introductory chapters by Keith Miller, Peter Winter and Leonard Firestone and myself. As editor, I have attempted above all else to ensure that the translation faithfully represents Overton's ideas and data, while making the material readily understandable to the modem scientific reader. This has frequently required that extremely long sentences, common in turn-of­ the-century German but considered cumbersome today, be simplified into two or even three sentences. In addition, I have paid particular attention to the correct translation of scientific terms, and I accept complete responsibility for any inaccuracies in this area. Overton's original contents list included headings and subheadings, but only a fraction of these appear in the original text. For the sake of clarity they have all been included in the body of the translated work. Also included is an index containing all chemicals mentioned in the book, along with their Chemical Abstracts System Registry Numbers for un­ ambiguous identification, a complete list of Overton's publications (Appendix B), and a list of all biographical articles about Overton and articles dealing specifically with analyses of his data (Appendix C).

Zielgruppe

Research

Autoren/Hrsg.

Lipnick, R. L.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete AINS Anästhesiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1 Introduction.- 2 Introduction.- 3 Charles Ernest Overton: narcosis studies and a contribution to general pharmacology.- Studies of Narcosis and a Contribution to General Pharmacology.- Preface.- One General Section.- 1 Background.- 2 Critical review of the major hypotheses on the mechanism of narcosis.- 3 Lipoid theory of narcosis and partition coefficients.- Two Experimental Results.- 4 Narcosis induced by ether and chloroform.- 4.1 Ether narcosis.- 4.2 Chloroform narcosis.- 5 Aliphatic non-electrolyte organic compounds and narcosis.- 5.1 Monohydric alcohols.- 5.2 Aliphatic hydrocarbons and their halogen derivatives.- 5.3 Nitriles and nitroparaffins.- 5.4 Monovalent aldehydes, paraldehyde, chloral hydrate and chloralformamide.- 5.5 Ketones, sulfonals, aldoximes and ketoximes.- 5.6 Esters of mineral acids.- 5.7 Esters of organic acids: significance of the rate of saponification, and effect of the presence of hydroxyl groups.- 5.8 Dihydric and polyhydric alcohols and some of their derivatives.- 5.9 Acid amides: urea and its derivatives.- 5.10 Chloralose.- 6 Aromatic compounds.- 6.1 Aromatic hydrocarbons and azobenzene.- 6.2 Phenols and their ethers, vanillin and piperonal.- 6.3 Oil of turpentine, camphor and volatile oils.- 6.4 Lactones and anhydrides.- 6.5 Acetanilide, methacetin and phenacetin.- 6.6 Additive effects of two or more non-specific narcotics.- 7 Inorganic anaesthetics.- 7.1 Carbon dioxide.- 7.2 Carbon disulphide.- 7.3 Nitrous oxide.- 8 Action of basic narcotics and basic compounds.- 8.1 Classification of the basic organic compounds according to their degree of alkalinity.- 8.2 Formation of salts with cell proteins.- 8.3 Action of some very weak organic bases.- 8.4 Action of some stronger organic bases.- 8.5 Similarities and differences in the action of non-specific narcotics and organic bases.- 8.6 Complexes of organic bases with tannins and proteins.- 8.7 Relationship between the constitution of an organic base and its physiological effect.- 9 Conclusion.- 9.1 Summary of some of the findings.- Appendix A Detoxification by means of dialysis.- Appendix B List of publications of Charles Ernest Overton.- Appendix C Publications about Overton and analyses of his data.