Peptide Science

Chemical Ligation, Lead Generation, and Therapeutic Advances
1. Auflage 2025
ISBN: 978-1-119-82467-1
Verlag: Wiley

Buch, Englisch, 600 Seiten

Understand the nature and applications of peptides with this clear and comprehensive guide
Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals.
Peptide Science offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it's a must-own for anyone looking to understand a vital field of chemistry.
Peptide Science readers will also find: - Through coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs
- Detailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more
- A section dedicated to key challenges and future directions in peptide therapeutics

Peptide Science is ideal for industry professionals and researchers in organic chemistry, peptide science/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences.

Autoren/Hrsg.

Liu, Fa

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

CONTENTS

 

 

Preface

List of contributors

 

Section I. New Development in Peptide Chemistry

Chapter 1. Chemical Peptide Ligations

Chapter 2. Protein and Peptide Ligation Using Peptide Ligases

Chapter 3. Modern Methods for Late-Stage Peptide Modification

 

Section II. Peptide Drug Hit Identification

Chapter 4. From Natural Products to Peptide Drugs

Chapter 5. Generating Phage Libraries Bearing Unnatural Pharmacophores

Chapter 6. Computational Peptide Design for Diverse Structures and Functions

 

Section III. Peptide Drug Lead Generation and Optimization

Chapter 7. Peptide Discovery: Lead Generation

Chapter 8. A Survey and Guide to the Development of Fatty Acid-Derivatized Peptide Therapeutics

 

Section IV. Peptide Drug Case Studies

Chapter 9. Insulin In Its Second Century: History, Evolution and Aspirations

Chapter 10. Incretins and Development of Incretin-based Therapeutics

Chapter 11. Peptide-Based Therapeutics for Inflammatory and Autoimmune Diseases

Chapter 12. Radioligand as a Unique Rising Modality for Cancer Diagnosis and Treatment

Chapter 13. Peptide-Small Molecule Drug Conjugates for Cancer, Metabolic Diseases and Beyond

Chapter 14. Emerging Landscape of Therapeutic Oligonucleotide Delivery by Cell-Penetrating Peptide

 

Section V. Peptide CMC and Regulatory

Chapter 15. Peptide Chemistry, Manufacturing and Controls

Über Autor(innen)

Fa Liu, PhD, is the CSO of Full-Life Technologies, which centers on targeted alpha-radionuclide therapies. Prior to joining Full-Life, he was the CEO and Co-founder of Focus-X Therapeutics (2020-2022), later acquired by Full-Life. Before founding Focus-X, Dr. Liu headed the Chemistry of Novo Nordisk US sites, and Calibrium LLC (acquired by Novo Nordisk) (2014-2020), and served as a Group Leader at the Eli Lilly Peptide Discovery (2009-2014). Prior to Lilly, Dr. Liu worked at National Cancer Institute as a Staff Scientist (2004-2009). He received his Ph.D. in Synthetic Organic Chemistry from Shanghai Institute of Organic Chemistry in 2004.