Genetics and Analysis of Quantitative Traits

1998
ISBN: 978-0-87893-481-2
Verlag: SINAUER ASSOC

Buch, Englisch, 980 Seiten, Book, Format (B × H): 187 mm x 236 mm, Gewicht: 1665 g

Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is up-to-date, comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics. Central concepts are developed from first principles and illustrated with wide-ranging examples. The book reflects the recent influx of quantitative-genetic thinking into evolutionary biology and includes the latest techniques for QTL (quantitative-trait loci) analysis. Although written as a general text in quantitative genetics, the book will also serve as a basic reference for the seasoned professional.Website http://nitro.biosci.arizona.edu/zbook/book.html

Zielgruppe

Lower undergraduate

Autoren/Hrsg.

Lynch, Michael

Walsh, Bruce

Inhaltsverzeichnis

I. FOUNDATIONS OF QUANTITATIVE GENETICS.- An Overview of Quantitative Genetics.- Properties of Distributions.- Covariance, Regression, and Correlation.- Properties of Single Loci.- Components of Genetic Variation for Multilocus Traits.- Sources of Environmental Variation.- Resemblance between Relatives.- Introduction of Matrix Algebra and Linear Models.- Analysis of Line Crosses.- Inbreeding Depression.- Matters of Scale.- II. Quantitative Trait Loci.- Polygenes and Polygenic Mutation.- Detecting Major Genes.- Principles of Marker-Based Analysis.- Mapping and Characterizing QTLs: Inbredline Crosses.- Mapping and Characterizing QTLs: Outbred Populations.- III. Estimation Procedures.- Parent-Offspring Regression.- Sib Analysis.- Twins and Clones.- Cross-Classified Designs.- Correlations between Characters.- Genotype x Environment Interaction.- Maternal Effects Sex Linkage and Sexual Dimorphism.- Threshold Characters.- Estimation of Breeding Values.- Variance-Component Estimation with Complex Pedigrees.- Appendices.- Expectations, Variances and Covariances of Compound Variables.- Path Analysis.- Further Topics in Matrix Algebra and Linear Models.- Maximum Likelihood Estimation and Likelihood-Ratio Tests.- Computing the Power of Statistical Tests.- Literature Cited.- Author Index.- Organism and Trait Index.- Subject Index.