The Cutaneous Lymphoid Proliferations

A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin
2. Revised Auflage 2016
ISBN: 978-1-118-77626-1
Verlag: Wiley

Buch, Englisch, 568 Seiten, Format (B × H): 216 mm x 282 mm, Gewicht: 1801 g

A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease.
- Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin
- Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing   the immunohistochemica nd molecular aspects of lymphoid neoplasia. 
- Each chapter contains an extensive array of  ‘clinical vignettes’ clearly showing the application of principles and treatment techniques discussed in the chapter
- Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the  interplay between the immune system in  the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail.
- Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition

Autoren/Hrsg.

Magro, Cynthia M

Crowson, A Neil

Mihm, Martin C

Mihm, Martin C.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Dermatologie

Inhaltsverzeichnis

Acknowledgments, viii

1 Introduction to the Classification of Lymphoma 1

Kiel Lukes–Collins, and Working Formulation classifications 1

WHO, REAL, EORTC, and the Combined WHO/EORTC classifications 2

Summary 7

References 8

Appendix: Definitions of key terms and techniques 9

2 The Therapy of Cutaneous T Cell Lymphoma 14
Benjamin H. Kaffenberger, Mark A. Bechtel, and Pierluigi Porcu

Introduction 14

Diagnostic work-up and staging procedures 14

CTCL therapies 15

Goals of therapy in advanced-stage CTCL 16

Extracorporeal photopheresis (ECP) 17

Interferons 17

Retinoids 17

Immunotoxins 18

Monoclonal antibodies 18

Histone deacetylase inhibitors (HDACi) 19

Antibody drug conjugates (ADC) 19

Cytotoxic chemotherapy 19

Investigational therapies 20

TLR agonists and cytokines 20

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) 20

References 21

3 Molecular Analysis in Cutaneous Lymphoid Proliferation 23
Shabnam Momtahen, Cynthia Magro, and Carl Morrison

Introduction 23

Immunoglobulin and T cell receptor structure 23

PCR design for determination of clonality 24

Detection of PCR products for clonality 24

Evaluation of results 25

The value and utility of molecular diagnostics in primary cutaneous lymphomas 26

Limitations of clonality assessment by PCR 27

Case vignettes 29

References 36

4 Benign Lymphocytic Infiltrates 37

Introduction 37

Spongiotic and eczematous dermatitis 37

Other spongiotic/eczematous tissue reactions 40

Other causes of subacute eczematous dermatitis 40

Interface dermatitis: cell-poor vacuolar interface dermatitis 42

Interface dermatitis: lichenoid pattern 46

Diffuse and nodular lymphocytic dermal infiltrates without atypia 51

Diffuse and nodular lymphocytic infiltrates associated with autoimmune disease 53

References 57

5 Reactive Lymphomatoid Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma 59

Lymphomatoid drug eruptions 59

Molecular profile of lymphomatoid drug eruptions 61

Pathogenetic basis of lymphomatoid drug reactions 62

Reactive lymphomatoid lesions encountered in lesions of collagen vascular disease 63

Angiomatous Variants of Pseudolymphoma 67

Case vignettes 69

References 86

6 Precursor Lesions of Cutaneous T Cell Lymphoma 89

Cutaneous T cell lymphoid dyscrasia 89

Large plaque parapsoriasis 90

Hypopigmented interface T cell dyscrasia: a unique indolent T cell dyscrasia 91

Pigmented purpuric dermatosis (PPD) 92

Pityriasis lichenoides 94

Idiopathic erythroderma (pre-Sézary) 96

Syringolymphoid hyperplasia with alopecia 96

Folliculotropic T cell lymphocytosis/pilotropic T cell dyscrasia 97

Idiopathic follicular mucinosis/alopecia mucinosa 98

Keratoderma-like T cell dyscrasia 99

Atypical lymphocytic lobular panniculitis 100

Case vignettes 102

References 132

7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin 134

Marginal zone lymphoma 134

Blastic marginal zone lymphoma 140

Epidermotropic marginal zone lymphoma 140

Castleman disease 141

Primary cutaneous plasmacytoma 142

Case vignettes 145

References 166

8 Primary Cutaneous Follicle Center Cell Lymphoma 169

Clinical features 169

Pathology 169

Phenotypic profile 171

Molecular studies 172

Pathogenesis 172

Cytogenetics 172

Case vignettes 174

Additional molecular and cytogenetic study 185

References 186

9 Primary Cutaneous Diffuse Large B-Cell Lymphoma Including the Leg Type and Precursor B Cell Lymphoblastic Lymphoma 187

Primary cutaneous diffuse large B cell lymphoma 187

Systemic diffuse large B cell lymphomas with a propensity to involve the skin 197

Case vignettes 200

Additional light microscopic, phenotypic, molecular, cytogenetic studies 210

References 215

10 Intravascular Lymphoma 218

Clinical features 218

Light microscopic findings 219

Phenotypic profile 219

Molecular and cytogenetic studies 219

Pathogenesis 219

Differential diagnosis 219

Intravascular anaplastic large cell lymphoma 219

Benign intravascular proliferations of histiocytes and reactive T cells 220

Case vignettes 221

References 224

11 Cutaneous Mantle Cell Lymphoma 225

Clinical features 225

Light microscopic findings 225

Phenotypic profile 226

Molecular studies 227

Cytogenetic profile 227

Pathogenesis 227

Case vignettes 229

Additional molecular and cytogenetic studies 233

References 234

12 Mycosis Fungoides and Sézary Syndrome 236

Definition 236

Mycosis fungoides 236

Sézary syndrome and erythrodermic mycosis fungoides 243

Large cell transformation of mycosis fungoides 251

Extracutaneous involvement in mycosis fungoides 254

Case vignettes 259

References 271

13 CD30-Positive Lymphoproliferative Disorders Including Lymphomatoid Papulosis, Borderline CD30-Positive Lymphoproliferative Disease, Anaplastic Large Cell Lymphoma, and T-Cell-Rich CD30-Positive Large B Cell Lymphoma 274

Introduction 274

Lymphomatoid papulosis 274

CD8+ lymphomatoid papulosis, including the type D variant 278

Type E lymphomatoid papulosis (Case vignette 15) 278

Borderline CD30-positive lymphoproliferative disorders (type C LYP) (Case vignette 9) 279

Lymphomatoid papulosis with a rearrangement of chromosome 6p25.3 279

Cutaneous anaplastic large cell lymphoma 280

Small cell ALCL 282

Additional unusual histologic variants of anaplastic large cell lymphoma 282

Breast-implant-associated anaplastic large cell lymphoma 282

Intravascular anaplastic large cell lymphoma 282

Sarcomatoid anaplastic large cell lymphoma (Case vignette 14) 283

CD30-positive large B cell lymphoma 285

Case vignettes 286

References 309

14 CD4+ Peripheral T Cell Lymphoma, Not Otherwise Specified, Including Primary Cutaneous Cd4+ Small/Medium-Sized Pleomorphic T Cell Lymphoma 312

Introduction 312

Primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma 312

CD30-negative large cell T cell lymphoma 313

Cutaneous follicular helper T cell lymphoma 314

Overview of overall prognosis of primary cutaneous peripheral T cell lymphoma, unspecified 315

Evolution of the nomenclature of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma 319

Case vignettes 320

References 333

15 Subcutaneous Panniculitis-Like T Cell Lymphoma 334

Clinical features 334

Morphology 336

Phenotype 337

Molecular studies 337

Differential diagnosis 337

Case vignettes 340

References 349

16 CD8 T Cell Lymphoproliferative Disease of the Skin 351

Overview 351

Introduction 351

Classification of primary CD8+ cutaneous T cell lymphomas 352

Histomorphology of primary cutaneous CD8+ T cell lymphoma: primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma, and CD8+ variants of peripheral T cell lymphoma, NOS, including primary cutaneous CD8+ granulomatous T cell lymphoma 353

CD8 variant of lymphomatoid papulosis and other related CD30-positive T cell lymphoproliferative disorders of CD8 subtype 354

Light microscopic findings 354

Indolent CD8 positive lymphoid proliferation of the face and other body sites including acral surfaces 355

CD8 prolymphocytic leukemia 355

CD8 pseudol

Über Autor(innen)

Cynthia M. Magro MD
Professor of Pathology and Laboratory Medicine
Department of Pathology, Cornell University
Weill Cornell Medicine
New York, NY, USA

A. Neil Crowson MD
Clinical Professor of Dermatology, Pathology, and Surgery
Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory
President of Pathology Laboratory Associates
Tulsa, OK, USA

Martin C. Mihm MD
Clinical Professor of Pathology and Dermatology, Harvard Medical School
Director of Melanoma Program, Dermatology, Brigham and Women’s Hospital
Co-Director of Melanoma Program, Dana-Farber and Brigham and Women’s Cancer Center
Director, Mihm Cutaneous Pathology Consultative Service
Brigham and Women’s Hospital
Boston, MA, USA