Handbook of the Extracellular Matrix

Biologically-Derived Materials
1. Auflage 2024
ISBN: 978-3-031-56362-1
Verlag: Springer

Buch, Englisch, 1326 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 2634 g

This book comprises of 6 sections covering the fundamentals of the extracellular matrix, as well as the development and challenges of using biologically-derived materials, and its advanced biomedical applications. The first section is dedicated to the extracellular matrix, while the other 5 sections are each dedicated to a particular type of material. This book reports the fundamentals of the extracellular matrix and its impact in the development of innovative materials; provides an overview of the advanced methodologies to develop biologically-derived materials; and describes the challenges of the synthesis and processing of the different materials. Furthermore, it presents the biological activities, structural and physicochemical properties of such materials, and the modification methods pursued to improve their inherent properties. The wide range of advanced applications are covered as well, including the combination with emerging technologies, underlying tissue-engineered scaffolding, drug delivery systems, 3D in vitro tissue and cancer models, 3D bioprinted models, bioinks, and more.

 This reference work serves as a core reference for multidisciplinary students (undergraduates and Ph.D. students) and a wide range of established researchers and professionals working in the medical field, e.g., orthopaedics, radiology, dentistry, and cancer.

Zielgruppe

Research

Autoren/Hrsg.

Maia, F. Raquel

Maia, Fatima Raquel Azevedo

Oliveira, J. Miguel

Reis, Rui L.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Naturwissenschaften Chemie Chemie Allgemein
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff

Inhaltsverzeichnis

Introduction (Editors)

Section 1: Fundamentals of the extracellular matrix

Chapter 1: Extracellular matrix composition

Nikos K. Karamanos: [e-mail] (Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece)

Chapter 2: The role of fibrous networks on the extracellular matrix mechanical properties

Fred W. Keeley: [e-mail] (Molecular Structure and Function Program, The Hospital For Sick Children, 555 University Ave, Toronto, Canada)

Chapter 3: Extracellular matrix structural features

Nikos K Karamanos: [e-mail] (Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece)

Chapter 4: Extracellular matrix bioactive molecules and cell behavior modeling

Ngan F. Huang: [e-mail] (Department of Cardiothoracic Surgery, Stanford University, Cardiovascular Institute, Stanford University, Stanford, CA, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Mail Code 153, Palo Alto, CA 94304)

Chapter 5: Mechanotransduction role at gene expression levels

Donald E. Ingber: [e-mail] (Wyss Institute for Biologically Inspired Engineering and the School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02139, USA)

Chapter 6: Extracellular matrix structure regulates local cell-matrix biomechanics

S. L. Voytik-Harbin: mail:[e-mail] (Weldon School of Biomedical Engineering/Dept. of Basic Medical Sciences, School of Veterinary Medicine, Lynn Hall, Purdue Univ., 625 Harrison St., West Lafayette, IN 47907-2026)

Chapter 7: Extracellular matrix isolation: sources and methods

Yong Yang: [e-mail] (Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA)

Chapter 8: Extracellular matrix and its involvement in tissue generation

Kwanwoo Shin: rk.ca.gnagos@nihswk (Department of Chemistry and Institute of Biological Interfaces, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Korea)

Chapter 9: Strategies for mimicking extracellular matrix

Laura Russo: [e-mail] (University of Milano-Bicocca, Department of Biotechnology and Biosciences, Piazza della Scienza 2, 20126 Milan, Italy)

Chapter 10: Extracellular matrix remodeling on cancer progression

Juliane Winkler: [e-mail] (Department of Anatomy, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94143, USA)

Section 2: Protein – based materials

Chapter 11: Development of protein-based materials

Lynne J. Regan: [e-mail] (Department of Molecular Biophysics and Biochemistry, Yale University)

Chapter 12: Production of protein-based scaffolds for tissue regeneration

Chaozong Liu: [e-mail] (Institute of Orthopaedic & Musculoskeletal Science, Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, United Kingdom)

Chapter 13: Protein – based nanoparticles as therapeutic carriers

Sonia Kapoor: [e-mail] (Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida 201 313, Uttar Pradesh, India)

Chapter 14: Innovative protein-based materials as cancer in vitro models

Qiang Wei: [e-mail] (Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China)

Chapter 15: Novel protein-based bioinks for tissue engineering

Amin Shavandi: [e-mail] (BioMatter Unit, École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium)

Chapter 16: Protein-derived 3D bioprinted models for tissue engineering

Sang Jin Lee: [e-mail] (Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA) Or João Costa: [e-mail] (3B’s Research Group, University of Minho)

Chapter 17: Protein-based microfluidic models for biomedical applications

Biman B Mandal: [e-mail] (Biomaterial and Tissue Engineering Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India)

Chapter 18: Functionalization of protein-based materials for biomedical applications

Thomas R. Scheibel: [e-mail] (Biomaterials, Faculty of Engineering Science, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany)

Chapter 19: Protein-based materials for the development of biosensors for biomedical applications

Vamsi Yadavalli: [e-mail] (Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, United States)

Chapter 20: Regulatory challenges of protein-based materials approaches to reach clinical trials

Glenn D. Prestwich: [e-mail] (Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA)

Section 3: Polysaccharide – based materials

Chapter 21: Polysaccharide-based materials: Synthesis and characterization

Dong-An Wang: [e-mail] (Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR)

Or Garima Agrawal: [e-mail] (School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Mandi, 175075, Himachal Pradesh, India)

Chapter 22: Polysaccharide-based hydrogels for advanced tissue engineering approaches

Cristina Barrias: [e-mail] (i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal)

Chapter 23: Polysaccharide-based bioinks for tissue engineering

Maurice Collins: [e-mail] (School of Engineering at the University of Limerick)

Chapter 24: Polysaccharide-based self-healing hydrogels

Jason A. Burdick: [e-mail] (Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA)

Chapter 25: Polysaccharide-based materials for tissue repair

Yuekun Lai: [e-mail] (National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University Suzhou 215123, P. R. China)

Chapter 26: Polysaccharide-based 3D model for cancer drug screening

Mary C. Farach-Carson: [e-mail] (Departments of Biochemistry and Cell Biology and Bioengineering, Rice University, Houston, Texas 77005, United States)

Chapter 27: Polysaccharide-based drug delivery systems

Sanjay Garg: [e-mail] (School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia)

Chapter 28: Polysaccharide-based materials for development of point-of-care devices

Ch. Mohan Rao: [e-mail] (Centre for Cellular and Molecular Biology, Uppal Road, Uppal, Hyderabad 500007, Telangana, India)

Chapter 29: Polysaccharide-based materials for scaffolds biofabrication

Giovanna Brusatin: [e-mail] (Department of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy)

Chapter 30: Polysaccharide-based materials for the development of wound healing strategies

Luís Cláudio Nascimento da Silva: [e-mail] or [e-mail] (Programa de Pós-graduação, Universidade Ceuma, São Luís, Maranhão 65075–120, Brazil)

Section 4: Cell - derived materials

Chapter 31: Decellularized cell-derived materials: production and characterization

Anna Blocki: [e-mail] (Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong)

Chapter 32: Generation of cell-derived matrices: different cellular sources

Cathal J. Kearney: [e-mail] (Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts, USA)

Chapter 33: Engineered decellularized cell-derived biomaterials

Todd C. McDevitt: [e-mail] (The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Georgia, USA)

Chapter 34: Modeling cell behavior through nanoengineered cell-derived materials

Pilnam Kim: [e-mail] (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea)

Chapter 35: Cell-derived materials and the host response

T R Kyriakides: [e-mail] (Department of Biomedical Engineering, Yale University, New Haven, CT, United States; Department of Pathology, Yale University, New Haven, CT, United States; Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, United States)

Chapter 36: Cell-derived matrices effects on macrophages response and wound healing

Ping Du: [e-mail] (Center for Human Tissues & Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China)

Chapter 37: Cell-derived matrices for biomedical applications

Jeffrey R. Morgan: [e-mail] (Brown University G-B, Providence, RI 02912, USA)

Chapter 38: Cell-derived matrices as microenvironment for in vitro 3D disease model

Takashi Hoshiba: [e-mail] (Frontier Center for Organic Materials, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan)

Chapter 39: Cell-derived matrices as scaffolds for bone tissue engineering

Changan Guo: [e-mail] (Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Xuhui District, Shanghai 200032, China)

Chapter 40: Cell-derived matrices as 3D tissue models

Elisabeth Engel: [e-mail] (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10-12, Barcelona, 08028 Spain)

Section 5: Tissue - derived materials

Chapter 41: Decellularized tissue-derived materials development

Xiaoming Li: [e-mail] (Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.)

Chapter 42: Innovative decellularized tissue-derived materials for biomedical applications

Maria José Oliveira: [e-mail] (i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal)

Chapter 43: Decellularized tissue-derived materials as injectable hydrogels for tissue repair

Feng Lu: [e-mail] (Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong 510515 People’s Republic of China)

Chapter 44: Decellularized tissue-derived materials as advanced bioinks

Ramille N. Shah: [e-mail] (Department of Materials Science and Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208 USA)

Chapter 45: Decellularized tissue-derived materials for 3D in vitro cancer models development

Yuzhen Ma: [e-mail] (Centre of Reproductive Medicine, Inner Mongolia Hospital, Hohhot 010021, Inner Mongolia, China)

Chapter 46: 3D models based on decellularized tissue-derived materials for improved preclinical testing

Sarah L. Nietzer: [e-mail] (Department Tissue Engineering and Regenerative Medicine, University Hospital Würzburg, Würzburg, Germany; Translational Center Regenerative Therapies, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany)

Chapter 47: Decellularized tissue-derived materials as scaffolds for tissue engineering

Ho-Hyun Kwak: [e-mail] (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 200-701, Korea.)

Chapter 48: Decellularized tissue-derived materials as platforms for in vitro disease modeling

Christine E. Schmidt: [e-mail] (J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. BMS J257, Gainesville, FL 32611, United States)

Chapter 49: Decellularized tissue-derived materials for grafts development

Lijiang Huang: [e-mail] (Science and Education Management Center, The Affiliated Xiangshan Hospital of Wenzhou Medical University, 291 Dandong Street, Ningbo, Zhejiang 315700, P.R. China)

Chapter 50: Host response to decellularized tissue-derived materials

David W. Grainger: [e-mail] (Department of Bioengineering, University of Utah, Salt Lake City, UT 84112-5820 USA)

Section 6: Marine - derived materials

Chapter 51: Isolation and Characterization of Marine-derived materials

Tiago Silva: [e-mail] (3B’s Research Group, University of Minho)

Chapter 52: Current marine-derived materials for tissue regeneration applications

Hojae Bae: [e-mail] (Department of Stem Cell and Regenerative Biotechnology, KU Convergence Science and Technology Institute, Konkuk University, Seoul 05029, Korea)

Chapter 53: Marine collagen for biomedical applications

Sik Yoon: [e-mail] (Department of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Korea.)

Chapter 54: Marine materials as bioinks for biomedical applications

Tao Xu: [e-mail] (Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing 100084, China)

Chapter 55: Marine-derived materials for development of advanced drug delivery systems

María-Dolores Veiga: [e-mail] (Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain)

Chapter 56: Antimicrobial marine-derived materials

Stefania Galdiero: [e-mail] (Department of Pharmacy, CIRPEB-University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy)

Chapter 57: Marine-derived materials for Hard Tissue Repair and Regeneration

Besim Ben-Nissan: [e-mail] (Advanced Tissue Regeneration & Drug Delivery Group, School of Life Sciences, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, Australia)

Chapter 58: Materials with marine origins for cancer therapy

Daquan Chen: Email: [e-mail] (Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs, Universities of Shandong, Yantai University, Yantai, 264005, China)

Chapter 59: Marine-derived materials for wound healing

Won-Kyo Jung: [e-mail] (Department of Biomedical Engineering, and Centre for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University, Busan 608-737, Republic of Korea)

Chapter 60: Marine-derived scaffolds for tissue engineering strategies

Hermann Ehrlich: [e-mail] (Institute of Experimental Physics, TU Bergakademie Freiberg, Leipziger Straße 23, 09599 Freiberg, Germany)

Über Autor(innen)

Fátima Raquel Maia obtained her Ph.D. in Biomedical Engineering from the University of Porto, in collaboration with the University of Nevada and University of Lisbon, in March 2014. In the same year, she started as a postdoctoral fellow at 3B’s Research Group. Since then, she has been engaged with several projects, concerning the development of bioengineered materials to model 3D native microenvironments for Tissue Engineering and Regenerative Medicine. In 2017, she was awarded an FCT postdoctoral fellowship, which gave place to a Junior Investigator contract under “Norma Transitória DL 57/2016 - Lei 57/2017”. She is currently focused her work on the development of bioengineered cell-derived materials envisioning the implementation of a new research line centered on the use of those matrices to model the dynamic microenvironment of native bone tissue.

Dr. Joaquim Miguel Oliveira, BSc, PhD is a senior researcher “Investigador FCT 2012 and FCT 2015” at the Portuguese Government Associate Laboratory ICVS/3B´s-University of Minho. Currently, he is a volunteer lecturer at the Faculty of Medicine, U. Porto and Dept. of Polymer Eng., UM. Since 2001, he has been involved in the development of biomaterials from natural origin for tissue engineering and regenerative medicine. His research activities have been increasingly focused on nanomedicine, stem cells and 3D in vitro models of disease.
Prof. Rui L. Reis, PhD, DSc, Hon. Causa MD (UGranada) is the Vice-Rector for R&D, Director of the 3B’s Research Group and of the ICVS/3B´s, of UMinho – Portugal. He is the CEO of the European Institute of Excellence on TERM, and the President-elect of Global TERMIS (Tissue Engineering & Regenerative Medicine International Society) and the editor-in-chief of the JTERM.