Gene Therapy for Neurological Disorders

Molecular Approaches for Targeted Treatment
1. Auflage 2024
ISBN: 978-1-77491-678-0
Verlag: Apple Academic Press

Buch, Englisch, 238 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 485 g

Neurological illnesses pose one of the biggest hazards to the healthcare system today. This new book brings together the latest methods of gene therapy that can be used to treat both inherited and sporadic neurodegenerative diseases. It presents the most significant advances in gene transfer methods as well as the most recent understandings of the mechanisms behind specific neurodegenerative illnesses, placing these into the context of gene therapy approaches for the central nervous system. The book introduces the basics of neurodegenerative conditions and the physiological basis for their occurrence in humans. It also discusses the various proteins useful in neuro diseases and their viral applications. The book explores how stem cells can be used to learn about the future of gene therapy along with the significance of the sequences that silence genes. It discusses the functions of astrocytes in different brain regions, as well as in-vivo research in gene therapy for neurodegenerative disorders.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Malviya, Rishabha

Singh, Arun Kumar

Goyal, Priyanshi

Sundram, Sonali

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

1. Neurodegenerative Disorders and Their Treatment 2. Neurodegenerative Disorder: A Mysterious Group of Diseases 3. Propagation of Neurodegenerative disorders4. Gene Therapy: A Promising Strategy for the Treatment of Brain Disease 5. Stem-Cell-Employed Gene Therapy for Neurodegenerative Disorder 6. Current Practice and Prospects in Gene Therapy Based on Genomic DNA 7. Targeting Oligodendrocytes with Gene-Silencing Sequences through Vector-Mediated Transgene Delivery 8. Astrocytes: Genetic Treatment Targets for Alzheimer‘s Disease 9. Clinical Studies of Gene Therapy for the Treatment of Neurodegenerative Disorders

Über Autor(innen)

Rishabha Malviya, PhD, is an Associate Professor of Pharmacy at the School of Medical and Allied Sciences, Galgotias University, Uttar Pradesh, India. He has authored more than 150 research and review papers for national and international journals of repute and has edited 13 books. He holds over 50 patents. Listed in the World’s Top 2% Scientists list by Elsevier BV and Stanford University, he is a reviewer, editor, and editorial board member of more than 50 national and international journals.

Arun Kumar Singh, MPharm, is affiliated with the Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Uttar Pradesh, India. His areas of interest include nanoformulation, blockchain, IoT, machine learning, cancer, artificial intelligence, and big data. He has published several book chapters in the field of big data as well as review papers.

Priyanshi Goyal, MPharm, is affiliated with the Department of Pharmacy at the School of Medical and Allied Sciences, Galgotias University, Uttar Pradesh India. She has authored a book chapter and is the author of one book from Apple Academic Press, Taylor and Francis Group. She earned her BPharm from Aligarh College of Pharmacy, Aligarh, affiliated with AKTU, Lucknow, and her MPharm from Galgotias University, Greater Noida, India.

Sonali Sundram, MPharm, is an Assistant Professor in the School of Medical and Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. Previously, she worked as a research scientist on a project of ICMR at King George’s Medical University, Lucknow, India; as well as at BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work was in neurodegeneration and nanoformulation. She has edited four books and has organized more than 15 national and international seminars, conferences, and workshops. She has several patents, both national and international, to her credit.