E-Book, Englisch, 321 Seiten, Web PDF
Maryanoff / Reitz Advances in Medicinal Chemistry
1. Auflage 1999
ISBN: 978-0-08-052637-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 321 Seiten, Web PDF
ISBN: 978-0-08-052637-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Autoren/Hrsg.
Weitere Infos & Material
1;Cover;1
2;CONTENTS;6
3;LIST OF CONTRIBUTORS;8
4;PREFACE;10
5;CHAPTER 1. NOVEL PEPTIDE MIMETIC BUILDING BLOCKS AND STRATEGIES FOR EFFICIENT LEAD FINDING;12
6;CHAPTER 2. RECENT ADVANCES IN THE MEDICINAL CHEMISTRY OF TAXOID ANTICANCER AGENTS;80
7;CHAPTER 3. SYNTHESIS AND STRUCTURE–ACTIVITY RELATIONSHIPS OF PEROXIDIC ANTIMALARIALS BASED ON ARTEMISININ;136
8;CHAPTER 4. DESIGN OF COMPOUND LIBRARIES FOR DETECTING AND PURSUING NOVEL SMALL MOLECULE LEADS;230
9;CHAPTER 5. A THEORETICAL MODEL OF THE HUMAN THROMBIN RECEPTOR (PAR-1), THE FIRST KNOWN PROTEASE-ACTIVATED G-PROTEIN-COUPLED RECEPTOR;256
10;CHAPTER 6. FARNESYL TRANSFERASE INHIBITORS: DESIGN OF A NEW CLASS OF CANCER CHEMOTHERAPEUTIC AGENTS;284
11;INDEX;326
