Cardiomyopathies and Heart Failure

Biomolecular, Infectious and Immune Mechanisms
2003
ISBN: 978-1-4020-7438-7
Verlag: Springer US

Buch, Englisch, Band 248, 531 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 1089 g

Reihe: Developments in Cardiovascular Medicine

DUCTORYCHAPTER CARDIOMYOPATHIESANDHEARTFAILURE Biomolecular,InfectiousandImmuneMechanisms AkiraMatsumori,MD,PhD DepartmentofCardiovascularMedicine KyotoUniversityGraduateSchoolofMedicine Kyoto,Japan 1 SUMMARY Theclinicalpresentationofviralmyocarditisisvariable. Whenmyocardial necrosis is diffuse, congestive heart failure develops, and later, dilated cardiomyopathy. If the myocardial lesions are localized, a ventricular aneurysmforms. Whencomplicatedbyarrhythmias,myocarditispresentsas arrhythmogenic right ventricular cardiomyopathy. When myocardial necrosisislocalizedtothesubendocardialregion,restrictivecardiomyopathy may develop. While it has not been established that hypertrophic cardiomyopathy maybeacomplicationofviral myocarditis, asymmetrical septal hypertrophy has, in fact, sometimesbeen observed in patients with myocarditis. TheimportanceofhepatitisCvirusinfectionhasrecentlybeen notedinpatientswithmyocarditis,dilatedandhypertrophiccardiomyopathy.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Matsumori, Akira

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms.- 1. Chemokines and Cardiovascular Diseases.- 2. Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation.- 3. The Interleukin-6 Family of Cytokines and their Receptors in Patients with Congestive Heart Failure.- 4. Animal Model of Cardiomyopathy Due to Overexpression of TNF-?.- 5. Myosin Autoreactive T Cells and Autoimmune Myocarditis: Lessons from the Disease Caused by Cardiac Myosin Peptide CM2.- 6. Autoimmunity in Cardiomyopathies.- 7. Anti-G-Protein Coupled Cardiac Receptor Autoantibodies In Dilated Cardiomyopathy.- 8. Clinical Significance of Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis.- 9. Development of Mast Cells: Process and Regulatory Mechanisms.- 10. Mast Cells in Experimental Myocardial Infarction.- 11. Possible Involvement of Mast Cells in the Development of Fibrosis.- 12. Human Mast Cell Chymase and 31 Amino Acid Endothelin-1.- 13. Tryptase From Human Mast Cells.- 14. Effects of the Tryptase Receptor Activating Peptide and Antibodies Against the Tryptase Receptor Par-2 On Neonatal Rat Cardiomyocytes in Culture.- 15. Role of Human Heart Mast Cells in Immunologic and Inflammatory Mechanisms Underlying Cardiovascular Disorders.- 16. Mast Cells in Atherosclerotic Human Coronary Arteries: Implications for Coronary Fatty Streak Formation and Plaque Erosion or Rupture.- 17. The Key Role of Mast Cells in the Evolution to Congestive Heart Failure.- 18. Links Between Viral Infections And Heart Disease.- 19. Molecular Detection and Characterization of Human Enteroviruses.- 20. Detection and Biological Implications of Genetic Memory in Viral Quasispecies.- 21. The Group B Coxsackieviruses as Vaccines and Vectors.- 22. Detection ofImportant Diagnostic Markers of HCV Infection.- 23. Large Animal Model of Viral Myocarditis.- 24. Hepatitis C Virus and Cardiomyopathy.- 25. Diagnosis and Treatment of Myocarditis: The Role of Adenovirus Infection in Cardiomyopathy and Heart Failure.- 26. The Natural History of Viral Myocarditis: Pathogenetic Role of Adrenergic System Dysfunction in the Development of Idiopathic Dilated Cardiomyopathy.- 27. Clinical Diagnosis of Myocarditis.- 28. Recent Advances in Giant Cell Myocarditis.- 29. Registry of Myocarditis and Heart Failure.- 30. Molecular Etiology of Idiopathic Cardiomyopathy.- 31. Gene-Based Therapy of Long QT Syndrome.- 32. How Does Adenosine Mediate Cardioprotection?.- 33. Protection of Cell Injury by Thioredoxin.- 34. Hematopoietic Stem Cells and Angiogenesis.- 35. Transplanting Cells for the Treatment of Cardiomyopathy.- 36. Toward an Ideal Large Animal Model Of Dilated Cardiomyopathy to Study Left Ventricular Volume Reduction Surgery.- 37. Heart Transplantation: 35 Years of Progress.- 38. Genes of the Major Histocompability Complex Class II Influence The Phenotype Of Cardiomyopathies Associated With Hepatitis C Virus Infection.