E-Book, Englisch, 662 Seiten
McAnulty / Dayan / Ganderup The Minipig in Biomedical Research
Erscheinungsjahr 2012
ISBN: 978-1-4398-1119-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 662 Seiten
ISBN: 978-1-4398-1119-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered.
The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.
Zielgruppe
Laboratory Animal Scientists; Pharmacologists and Toxicologists; Biomedical Scientists, Laboratory Veterinarians, Veterinary Technicians
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Veterinärmedizin Veterinärmedizin: Labortiere, Tierversuche
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
Weitere Infos & Material
Origin and Management of the Minipig
History and Development of Miniature, Micro- and Minipigs
Friederike Köhn (Germany)
Husbandry and Management
Roberta Scipioni Ball (USA)
Diseases of Minipigs
Nanna Grand (Denmark)
International Transportation of Minipigs
Finn Raaschou-Nielsen (Denmark)
Welfare and Experimental Usage of the Minipig
Ethical Issues in the Use of Minipigs in Animal Research
David Morton (UK)
Animal Welfare Issues
M. Michael Swindle (USA), Alison C. Smith (USA), and Kathy E. Laber (USA)
Stress in Experiments
Larry Brown (USA) and L. Peter Gade (Denmark)
Dosing Methods
Peter Clausing (Germany)
In-life Clinical Observations
David Cameron (UK)
Pharmacology and ADME Studies in the Minipig
Minipigs in Absorption, Distribution, Metabolism and Excretion (ADME) Studies
Cornelia Preusse (Germany) and Mette T. Skaanild (Denmark)
Safety Pharmacology
Stephane Milano (France)
Safety Assessment in the Minipig – Principal Body Systems
Dermal Toxicity Studies: Skin Architecture, Metabolism, Penetration and Toxicological and Pharmacological Methods
Andy Makin (Denmark), Jens Thing Mortensen (Denmark), and Bill Brock (USA)
Gastrointestinal Tract
Chris Van Ginneken (Belgium)
Heart and Cardiotoxicity
James R. Turk (USA)
Central and Peripheral Nervous Systems
Alan D Rasmussen (Denmark) and Karen M. Wegener (Denmark)
The Kidney
Peter A. McAnulty (Denmark)
Reproductive System including Studies in Juvenile Minipigs
Paul Barrow (France), Edward Marsden (France), and Peter A. McAnulty (Denmark)
The Endocrine System
Claudia Stark (Germany) and Jakob Walter (Germany)
Skeletal System
Hideki Tsutsumi (Japan)
Ocular Examination and Background Observations
Helmut Ehall (UK)
Spontaneous/Background Pathology of the Göttingen Minipig
Mikala Skydsgaard (Denmark) and Zuhal Dincer (UK)
Genetics and Immunology
A Comparative Assessment of the Pig, Mouse, and Human Genomes: Structural and Functional Analysis of Genes Involved in Immunity and Inflammation
Harry Dawson (USA)
The Immune System of Pigs: Structure and Function
Patrick Haley (USA)
Allotransplantation in Miniature Swine
John S. Hanekamp (USA), Raimon Duran-Struuck (USA), and David H. Sachs (USA)
Xenotransplantation
Henk-Jan Schuurman (USA), Melanie L. Graham (USA), Thomas Spizzo (USA), and Clive Patience (UK).
Porcine endogenous retroviruses (PERVs) in xenotransplantation - A review of the importance of PERVs in porcine studies, with particular emphasis on the minipig
Linda Scobie (UK) and Olga Garkavenko (New Zealand)
Immunotoxicity Studies in Minipigs
André Penninks (The Netherlands) and Geertje J.D. van Mierlo (The Netherlands)
Disease Models
Creation and conservation of genetically modified pigs: applications to genetic disease model and xenotransplantation
Hiroshi Nagashima (Japan), Hitomi Matsunari (Japan), and Kazuhiro Umeyama (Japan)
Stem Cell Research and Minipigs
Vanessa J Hall (Denmark), Stoyan G Petkov (Denmark), and Poul Hyttel (Denmark)
Minipig Models of Diabetes Mellitus
Dwight A. Bellinger (USA), Elisabeth P. Merricks (USA), and Timothy C. Nichols (USA)
Diet-induced Atherosclerosis
James R. Turk (USA) and Maurice H. Laughlin (USA)
Haemorrhage and Resuscitation Models Using Miniature Swine
John Burns (USA) and Charles Wade (USA)
Oral Biology and Dental Models
Sue Herring (USA), Yiming Li (USA), Yi Liu (USA), Professor Zi Jun Liu (USA), Tracy Popowics (USA), Katherine Rafferty (USA), and Songlin Wang (China)
Osteoporosis Model in Minipigs
Hideki Tsutsumi (Japan), Satoshi Ikeda (Japan) Toshitaka Nakamura (Japan)
Wound Healing Models
Peter Glerup (Denmark)
The Minipig in Chemical, Biological and Radiological Warfare Research
Stanley S. Hulet (USA), Maria Moroni (USA), Mark H Whitnall (USA), and Robert J Mioduszewski (USA)
The Minipig and Pig in Medical Device Research
Shayne C. Gad (USA)
Regulatory Perspective and Use of the Minipig in Developing Marketed Products
Regulatory Aspects – Pharmaceuticals, Medical Devices and Food Additives
Abigail Jacobs (USA) and Jan-Willem van der Laan (The Netherlands)
Adverse Responses to Drugs in Man: a critical comparison of reported toxicological findings in minipigs and humans
Niels-Christian Ganderup (Denmark)
Regulatory Acceptance of the Minipig in Non-Pharmaceutical Industry and Research
Warren Harvey (UK)
New Horizons and perspectives
Future Prospects: Possibilities and Perspectives
Anthony D. Dayan (UK)