Mechanisms and Therapy of Liver Cancer

Erscheinungsjahr 2021
ISBN: 978-0-12-824030-4
Verlag: William Andrew Publishing

Buch, Englisch, 402 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 750 g

Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.

Zielgruppe

<p>Researchers and students in basic and translational cancer research, with special emphasis on liver diseases and liver cancer, as well as related areas in genetics, immunology, pharmacology and cell and molecular biology</p>

Autoren/Hrsg.

Weitere Mitwirkende

Sarkar, Devanand

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hepatologie

Inhaltsverzeichnis

1. Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
Saranya Chidambaranathan-Reghupaty, Paul B. Fisher, and Devanand Sarkar
2. Signaling pathways in hepatocellular carcinoma
Teresa Garcia-Lezana, Juan Luis Lopez-Canovas, and Augusto Villanueva
3. Hepatitis C virus associated hepatocellular carcinoma
Mousumi Khatun, Ranjit Ray, and Ratna B. Ray
4. NAFLD-related HCC
Bubu A. Banini and Arun J. Sanyal
5. Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome
Rachel M. Golonka and Matam Vijay-Kumar
6. Systemic therapy of liver cancer
Tarik Demir, Sunyoung S. Lee, and Ahmed O. Kaseb
7. Immunotherapy in hepatocellular cancer
Christos Fountzilas, Rachel Evans, Sabah Alaklabi, and Renuka Iyer
8. Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression
Alphonse E. Sirica, Mario Strazzabosco, and Massimiliano Cadamuro

Über Autor(innen)

Sarkar, Devanand
Dr. Sarkar received his MBBS from Dhaka Medical College, Bangladesh and PhD from Nagoya University, Japan. After postdoctoral training in Columbia University, NY he joined Virginia Commonwealth University (VCU) as a faculty where he is now a Professor in the Department of Human and Molecular Genetics, and Associate Director of Education and Training at Massey Cancer Center. Dr. Sarkar's research focuses on identifying novel regulators of hepatocellular carcinoma (HCC), especially obesity-induced HCC, and developing targeted gene- and immunotherapy based on the accrued knowledge. Dr. Sarkar has published more than 280 papers and his research is funded by NCI, NIDDK and DOD.