Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases, Volume 155

Erscheinungsjahr 2020
ISBN: 978-0-12-823121-0
Verlag: ACADEMIC PR INC

Buch, Englisch, Band 155, 322 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 630 g

Reihe: International Review of Neurob

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain - A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more.

Zielgruppe

<p>Postgraduates and researchers in the areas of Neurobiology, Neurodegeneration, Alzheimer's, Parkinson's, Metabolic Disorders, Bioenergetics, Repurposing of Metabolic Treatments, Novel Treatments for Neurodegenerative Disorders.</p>

Autoren/Hrsg.

Weitere Mitwirkende

Söderbom, Gra&

Esterline, Russell

Oscarsson, Jan

Mattson, Mark P.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Alzheimer und Demenz
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Stoffwechselstörungen
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

1. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative diseases
Kenneth Maiese
2. Antidiabetic drugs for Alzheimer´s and Parkinson´s diseases: Repurposing insulin, metformin and thiazolidinediones
Susana Cardoso and Paula I. Moreira
3. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases
Christian Hölscher
4. Repurposing GLP1 agonists for neurodegenerative diseases
Ioanna Markaki, Kristian Winther, Sergiu-Bogdan Catrina and Per Svenningsson
5. A role for Sodium Glucose coTransporter 2 inhibitors (SGLT2i) in the treatment of Alzheimer's disease?
Russell Esterline, Jan Oscarsson and Jeffrey Burns
6. Ketotherapeutics for neurodegenerative diseases
Nicholas G. Norwitz, Javier Gilbert Jaramillo, Kieran Clarke and Adrian Soto
7. Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Yahyah Aman, Brent Ryan, Silje Bøen Torsetnes, Anne-Brita Knapskog, Leiv Otto Watne, William A. McEwan and Evandro Fei Fang
8. Cellular senescence in aging and age-related disorders: Implications for neurodegenerative diseases
Erin O. Wissler Gerdes, Yi Zhu, Bettina M. Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkonia and James L. Kirkland
9. Harnessing neurogenesis in the adult brain-A role in type-2-diabetes mellitus and Alzheimer's disease
Orly Lazarov, Richard D. Minshall and Marcelo G. Bonini
10. Hormesis: A therapeutic strategic approach in the treatment of neurodegenerative disease
Edward J. Calabrese, Mark P. Mattson, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese and James Giordano

Über Autor(innen)

Mattson, Mark P.
Dr. Mattson is a Professor of Neuroscience at Johns Hopkins University School of Medicine. After receiving his PhD degree from the University of Iowa, Dr. Mattson completed a postdoctoral fellowship in Developmental Neuroscience at Colorado State University. He then joined the Sanders-Brown Center on Aging at the University of Kentucky College of Medicine where he advanced to Full Professor. From 2000-2019 Dr. Mattson was the Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore where he brought neuroscience research to the forefront at that NIH Institute. Dr. Mattson's research is aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. His work has elucidated how the brain responds adaptively to challenges such as fasting and exercise, and he has used that information to develop novel interventions to promote optimal brain function throughout life. Dr. Mattson is among the most highly cited neuroscientists in the world with over 150,000 citations and an 'h' index of over 200. He was elected a Fellow of the American Association for the Advancement of Science, and has received many awards including the Metropolitan Life Foundation Medical Research Award, the Alzheimer's Association Zenith Award and the Santiago Grisolia Chair Prize. He was the founding Editor and Editor-in-Chief of Ageing Research Reviews and Neuromolecular Medicine, and is currently a Reviewing or Associate Editor for the Journal of Neuroscience and Trends in Neurosciences.

Esterline, Russell
Russell Esterline, PhD is currently a VP Global Medicines Leader at AstraZeneca Pharmaceuticals leading the advancement of late stage metabolic products towards registration and approval and beyond. He received his B.S. in Chemistry from Juniata College and his PhD in Toxicology from Rutgers University/UMDNJ Joint Graduate Program in Toxicology. He completed his Post-Doctoral training at the Johns Hopkins School of Hygiene and Public Health. Both pre- and post-graduate research focused on the impact of toxicants on mitochondrial function. At AstraZeneca, Russell led the development of CRESTOR (rosuvastatin) through its LCM delivery stage (METEOR, CORONA, AURORA, JUPITER, SATURN clinical trials) and more recently led the development of FARXIGA (dapagliflozin) through global approval and launch. As the FARXIGA lead, Russell became interested in understanding the underlying mechanism(s) behind the unique SGLT2i-driven benefit in patients with type 2 diabetes and has published a novel theory describing the metabolic underpinning of this benefit. If correct, this theory may have implications beyond the proven benefits on the heart and kidney into the CNS, a possibility which is currently being pursued through collaborations with leading scientists in the field.

Oscarsson, Jan
Jan Oscarsson is MD, PhD in Physiology and Registered physician trained in internal medicine. He was appointed Professor in Physiology, especially Endocrinology and Integrative metabolism, in 2003 and was recruited by AstraZeneca R&D the same year. His academic work has focused on metabolic regulation in cell culture, animal and clinical studies. He has also been interested in the hormonal regulation of neurogenesis in collaboration with the late Professor Peter Eriksson. At AstraZeneca R&D, he has had several different positions in R&D, including Head of Section of Molecular Metabolism and Disease Area Portfolio Leader focusing on diabetes and metabolic regulation. Since 2013, he is Director Physician in Clinical Development, working on type 2 diabetes, dyslipidemia and fatty liver disease. During the last few years he has conducted studies to determine the mechanisms behind the unique SGLT2i-driven benefits in patients with type 2 diabetes, and together with Russ Esterline PhD, published a novel theory describing the metabolic underpinning of this benefit.