Mihich Immunity, Cancer, and Chemotherapy

Basic Relationship on the Cellular Level
1. Auflage 2013
ISBN: 978-1-4832-5900-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 414 Seiten, Web PDF

Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects of immunosuppressive drugs on cellular changes after antigenic stimulation and specialized cell function in the lymphoid and reticuloendothelial cell series. Topics include effects of immunosuppressive drugs on the sensitization process; cellular changes in lymphoid tissue following sensitization; and demonstration of differences in antigen handling among cells of the reticuloendothelial system. The text also takes a look at allogeneic inhibition and its possible relation to cell-bound immunity in vitro and the effects of immunosuppressive drugs at various stages of differentiation of immunologically competent cells. The publication examines a study of antibody-containing cells in the course of immunization and cellular differentiation during immune responses studied with electron microscope and radioautography. The text also elaborates on ambiguity in the translation of genetic code into proteins, induced by aminoglycoside antibiotics and immunosuppressive agents and cellular kinetics of immune response. The selection is a dependable source of information for readers interested in effects of drugs on antibody response and transplantation immunity.

Autoren/Hrsg.

Mihich, Enrico

Inhaltsverzeichnis

1;Front Cover;1
2;Immunity, Cancer, and Chemotherapy: Basic Relationships on the Cellular Level;4
3;Copyright Page;5
4;Table of Contents;20
5;Participants;6
6;Contributors;10
7;Foreword;14
8;Preface;16
9;Chapter 1. The Effect of Immunosuppressive Drugs on Cellular Changes after Antigenic Stimulation;26
9.1;I. CELLULAR CHANGES IN LYMPHOID TISSUE FOLLOWING SENSITIZATION;27
9.2;II. EFFECT OF IMMUNOSUPPRESSIVE DRUGS ON THE SENSITIZATION PROCESS;30
9.3;III. CONCLUSIONS;35
9.4;References;37
9.5;DISCUSSION;38
10;Chapter 2. Specialized Cell Function in the Lymphoid and Reticuloendothelial Cell Series;42
10.1;I. DEMONSTRATION OF DIFFERENCES IN ANTIGEN HANDLING AMONG CELLS OF THE RETICULOENDOTHELIAL SYSTEM;43
10.2;II. SPECIALIZATION OF CELLS OF THE LYMPHOID SYSTEM;59
10.3;III. CONCLUDING REMARKS;67
10.4;References;68
10.5;DISCUSSION;69
11;Chapter 3. Allogeneic Inhibition and Its Possible Relation to Cell-Bound Immunity in Vitro;76
11.1;I. ATTEMPTS TO DEMONSTRATE ALLOGENIC INHIBITION IN VITRO;77
11.2;II. SUMMARY;85
11.3;Acknowledgments;85
11.4;References;85
11.5;DISCUSSION;86
12;Chapter 4. The Effect of Immunosuppressive Drugs at Various Stages of Differentiation of Immunologically Competent Cells;96
12.1;I. DEFINITION OF THE INDUCTIVE PHASE BY THE USE OF METABOLIC INHIBITORS;98
12.2;II. THE INFLUENCE OF METABOLIC INHIBITORS ON ANTIBODY PRODUCTION;108
12.3;III. THE INFLUENCE OF INHIBITORS ON THE PREPARATION FOR THE SECONDARY RESPONSE;109
12.4;IV. THE INFLUENCE OF INHIBITORS ON THE SECONDARY RESPONSE;113
12.5;V. STUDIES ON IMMUNOLOGICAL INHIBITION (TOLERANCE) USING METABOLIC INHIBITORS;114
12.6;VI. UNITARIAN CONCEPT OF IMMUNE REACTIONS BASED ON THE MODEL OF IMMUNOLOGICAL CELL DIFFERENTIATION;118
12.7;References;121
12.8;DISCUSSION;124
13;Chapter 5. A Study of Antibody-Containing Cells in the Course of Immunization;128
13.1;I. COMPARISON BETWEEN THE RESULTS OBTAINED WITH THE ICA AND THE HEMOLYSIS PLAQUE FORMATION TECHNIQUES;131
13.2;II. APPLICATION OF THE ICA METHOD TO THE STUDY OF CELLS PRODUCING ANTIBODIES AGAINST HAPTENS;138
13.3;III. INHIBITION OF ICA BY HETEROLOGOUS ANTIBODIES AGAINST IMMUNOGLOBULINS;139
13.4;IV. KINETICS OF THE APPEARANCE OF "ROSETTE"-FORMING CELLS IN THE SPLEEN OF MICE IMMUNIZED INTRAVENOUSLY WITH SHEEP ERYTHROCYTES;141
13.5;References;155
13.6;DISCUSSION;156
14;Chapter 6. Cellular Differentiation during Immune Responses Studied with the Electron Microscope and Radioautography;166
14.1;References;175
14.2;DISCUSSION;177
15;Chapter 7. Concerning the Recognition Reaction and Transfer RNA in Protein Synthesis;180
15.1;References;188
15.2;DISCUSSION;189
16;Chapter 8. Ambiguity in the Translation of the Genetic Code into Proteins, Induced by Aminoglycoside Antibiotics;192
16.1;References;197
16.2;DISCUSSION;198
17;Chapter 9. Macrophage RNA and Antibody Synthesis;202
17.1;References;207
17.2;DISCUSSION;207
18;Chapter 10. The Role of Antigen in the Regulation of Antibody Formation;212
18.1;I. KINETICS OF ANTIBODY FORMATION TO BACTERIOPHAGE f. 174 IN GUINEA PIGS;212
18.2;References;222
18.3;DISCUSSION;222
19;Chapter 11. Alteration of Immunity by Antimetabolites;228
19.1;References;234
19.2;DISCUSSION;235
20;Chapter 12. Immunosuppressive Agents and the Cellular Kinetics of the Immune Response;242
20.1;I. INTRODUCTION;242
20.2;II. MATERIALS AND METHODS;246
20.3;III. RESULTS;250
20.4;IV. DISCUSSION;253
20.5;V. SUMMARY;261
20.6;Acknowledgments;261
20.7;References;261
20.8;DISCUSSION;262
21;Chapter 13. Immunochemical Studies of Mammalian Cell Membranes;268
21.1;I. INTRODUCTION;268
21.2;II. THE IMMUNOCHEMICAL PROBLEM;269
21.3;III. METHODS FOR THE PREPARATION OF PLASMA MEMBRANES;272
21.4;IV. RECOGNITION MARKER FOR PLASMA MEMBRANE;275
21.5;V. COMPOSITION OF PLASMA MEMBRANE PREPARATIONS;279
21.6;VI. GENERAL DISCUSSION;281
21.7;References;283
21.8;DISCUSSION;284
22;Chapter 14. Tumor Antigens;290
22.1;References;299
22.2;DISCUSSION;300
23;Chapter 15. Expression of Antigens in Normal Mammalian Cells;306
23.1;I. INTRODUCTION;306
23.2;II. CELLULAR ANTIGENS IN TISSUE CULTURE;307
23.3;III. EMBRYONIC DIFFERENTIATION OF ANTIGENS;310
23.4;IV. INDUCTION OF ANTIGENS IN THE THYMUS;316
23.5;V. MODIFICATION OF THE EXPRESSION OF NORMAL TISSUE ANTIGENS IN VIVO;319
23.6;VI. DIFFERENTIATION OF IMMUNOGLOBULIN-PRODUCING CELLS;324
23.7;VII. CLOSING COMMENTS;326
23.8;References;327
23.9;DISCUSSION;331
24;Chapter 16. Mechanism of Complement Action and Means of Complement Depletion;336
24.1;I. PHYSIOGENIC AND PATHOGENIC ROLE OF COMPLEMENT;336
24.2;II. MECHANISM OF ACTION OF HUMAN COMPLEMENT;338
24.3;III. ENHANCEMENT OF COMPLEMENT;339
24.4;IV. INHIBITION OF COMPLEMENT;339
24.5;V. INACTIVATION OF C'3 BY COBRA FACTOR;339
24.6;References;341
24.7;DISCUSSION;341
25;Chapter 17. Immunogenicity of Synthetic Polymers of Amino Acids; Role of Carrier and Genetic Background;344
25.1;I. INTRODUCTION;344
25.2;II. IMMUNOGENICITY OF LINEAR POLYMERS OF a-L- AND a-D-AMINO ACIDS;345
25.3;III. ROLE OF CARRIER IN INFLUENCING THE IMMUNE RESPONSE;354
25.4;IV. GENETIC CONTROL OF IMMUNE RESPONSE;360
25.5;References;370
25.6;DISCUSSION;372
26;Chapter 18. Studies on Transplantation;376
26.1;I. PAST EFFORTS;376
26.2;II. CAUSES OF FAILURE;378
26.3;III. HISTOCOMPATIBILITY MATCHING;379
26.4;IV. IMPROVED IMMUNOSUPPRESSION;381
26.5;V. OTHER ORGANS;385
26.6;References;386
26.7;DISCUSSION;387
27;Author Index;392
28;Subject Index;406