G Protein Methods and Protocols

Role of G Proteins in Psychiatric and Neurological Disorders
1997. Auflage 1997
ISBN: 978-0-89603-490-7
Verlag: Humana Press

Buch, Englisch, Band 31, 433 Seiten, Format (B × H): 161 mm x 237 mm, Gewicht: 898 g

Reihe: Neuromethods

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.

Zielgruppe

Research

Autoren/Hrsg.

Mishra, Ram K

Baker, Glen B

Boulton, Alan A

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Psychiatrie, Sozialpsychiatrie, Suchttherapie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

In Vitro Autoradiographic Localization of Receptor-Stimulated [35S]GTP?S Binding in Brain.- Small-Molecular-Weight G Proteins.- G Proteins in the Etiology and Treatment of Mental Disorders.- G Protein ?- and ??-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interactions.- Modulation of G Proteins in Rat Striatum by Neuroleptic Drugs and a Peptidomimetic Analog of Pro-Leu-Gly-NH2.- G Proteins and Animal Models of Parkinson’s Disease.- Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling.- Molecular Mechanisms of Opiate Addiction in the Nucleus Accumbens.- G Protein-Linked Opioid Receptors.- G Protein-Coupled melatonin receptors.- G Proteins in the Pathophysiology and Treatment of Mood and Anxiety Disorders.- Determination of Adenosine Receptor-G Protein Coupling.- G Proteins and Mood Disorders.- G Proteins in the Medial Temporal Lobe in Schizophrenia.- G Protein Abnormalities in Schizophrenia.