Mochizuki / Takeda / Nagano The Ischemic Heart

Erscheinungsjahr 2007
ISBN: 978-0-585-39844-0
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 1, 575 Seiten, eBook

Reihe: Progress in Experimental Cardiology

Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries. The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.

Zielgruppe

Research

Autoren/Hrsg.

Mochizuki, Seibu

Takeda, Nobuakira

Nagano, Makoto

Dhalla, Naranjan S.

Inhaltsverzeichnis

Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury.- Function of Cardiac Myocytes in Ischemicheart Disease: Comparative Changes in Right and Left Ventricular Cells.- Remodeling of Cardiac Myocytes in Chronic Heart Disease.- Hibernating Myocardium.- Length-Dependent Modulation of Cardiac Muscle Contractility in Normoxia, Hypoxia, and Acidosis: Possible Implications for Ischemia.- Roles of Superoxide, Nitric Oxide, and Peroxynitrite in Various Pathological Conditions.- Real-Time Measurement of Nitric Oxide in Coronary Outflow during Transient Myocardial Ischemia and Reperfusion.- Production of Hydrogen Peroxide During Hypoxia-Reoxygenation in Isolated Myocytes.- Oxygen Free Radicals Enhance Ergonovine-Induced Canine Coronary Vasoconstriction.- Structure and Expression of Calponin in Arterial Smooth Muscle Cells.- Status of ?-Adrenoceptors, G-Proteins, and Adenylyl Cyclase in Ischemic Heart Disease.- Oxygen Consumption and Mitochondrial Membrane Potential in Postischemic Myocardium.- Pathophysiological Behavior of the Myocardium in Acute Ischemia and Reperfusion, with Special Emphasis on the Sarcoplasmic Reticulum.- Ca2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury.- Ionic Mechanisms of Reperfusion Injury.- Mechanism of Inhibition of Na+-H+ Exchanger (NHE1) by ATP Depletion: Implications for Myocardial Ischemia.- The Source and Fate of Protons in the Reperfused Ischemic Heart.- Intracellular Calcium Regulation in Cardiac Cells during Acidosis.- Intracellular pH Regulation and Myocardial Ischemia-Reperfusion Injury.- Regulation of [Na+ i and [Ca2+]i during Myocardial Ischemia and Reperfusion in a Single-Cell Model.- ATP-Sensitive Potassium Channels and Myocardial Ischemia.- Preconditioning and Protection of Ischemia-Reperfusion Injury.- Earlyand Delayed Protection Against Ventricular Arrhythmias Induced by Preconditioning.- Effects of Ischemic Preconditioning on Na+-Ca2+ Exchanger Activity and Ion Regulation in Isolated Perfused Rat Hearts.- Long-Term but not Short-Term Cardioprotection can be Induced by Preconditioning in Hypercholesterolemia.- Contribution of Endogenous Catecholamines to Preconditioning: Is it through Facilitation of Adenosine Production?.- Hypoxic Preconditioning of Isolated Cardiomyocytes of Adult Rat.- Pharmacological Modification of Ischemic Preconditioning During Percutaneous Transluminal Coronary Angioplasty.- Protection Against Injury Durin Gmyocardial Ischemia and Reperfusion: Concepts and Strategies.- Mechanisms of Cardioprotective Effects of Propranolol Against Reperfusion Injury.- Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion.- Thioctic Acid Prevents Oxidativedamage in Isolated Cardiac Myocytes.- Transfection of Heat-Shock Protein 70 Enhances Myocardial Tolerance to Ischemia: Evidence for a Role of HSP70 in Ischemia-Reperfusion Injury.- Calcium but not Amiloride Improves the Mechanical Function of Reperfused One-Week-Old Rabbit Hearts.- Effects of BIBR-277, an Angiotensin-II Type-1 Receptor Antagonist, on Ischemic Myocardial Stunning in Dogs.- Reperfusion 12 Hours after Coronary Occlusion Salvages Myocardium in Dogs: Studies in a Single-Heart Model.- Ecto-5?-Nucleotidase and Cardioprotection.- Limitation of Stunning in Dog Myocardium by the Nucleoside-Nucleotide Mixture OG-VI.- Decrease in Myocardial Ischemic Tolerance with Aging in Fischer 344 Rats.- Underperfusion Injury in Diabetic Rat Hearts: Effects of Norepinephrine and/or Insulin on Stiffness Increase and Abnormal Energy Metabolism.- Do KetoneBodies Contribute to Protection against Damage Caused by Bothmyocardial Ischemia and Reperfusion Injury?.- Effect of Basic Fibroblast Growth Factor on the Regional Myocardial Blood Flow of Acutely Infarctedmyocardium in Experimental Animals.- Intramyocardial Ejection of Basic Fibroblast Growth Factor Increased Regional Myocardial Blood Flow Andsalvaged Infarcted Myocardium in Dogs.- Effect of Basic Fibroblast Growth Factor on the Regional Myocardial Blood Flow in Acutely Infarcted Myocardium in Rats.- Gene Therapy for Myocardial Infarction.- Adenoviral Vectors as Experimental and Therapeutic Tools.- Prevention of Transplantation-Associated Arteriosclerosis by Antiadhesion Therapy.