Modifications of Nuclear DNA and its Regulatory Proteins

Erscheinungsjahr 2011
ISBN: 978-0-12-387685-0
Verlag: William Andrew Publishing

Buch, Englisch, 502 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 810 g

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Zielgruppe

<p>Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.</p>

Autoren/Hrsg.

Weitere Mitwirkende

Cheng, Xiaodong

Blumenthal, Robert M.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Introduction – Epiphanies in Epigenetics
Xiaodong Cheng and Robert M. Blumenthal

Section I. EVOLUTION OF DNA METHYLATION
2. The natural history of eukaryotic DNA methylation systems
Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
3. Evolution of histone methyltransferases and demethylases
L. Aravind
4. DNA methylation in Drosophila – A critical evaluation
Veiko Krauss and Gunter Reuter
5. DNA Methylation in Zebrafish
Mary G Goll and Marnie E Halpern

Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION
6. Dnmt1 - structure and function
Željko M. Svedružic
7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
Frédéric Chédin

Seciton III. DNA METHYLATION AND DEMETHYLATION
8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
Jafar Sharif & Haruhiko Koseki
9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
Shannon R. Morey Kinney and Sriharsa Pradhan
10. Mechanistic and functional links between histone methylation and DNA methylation
Taiping Chen

Section IV. DNA METHYLATION IN MEDICINE
11. RNA mediated silencing mechanisms in mammalian cells
Anton Wutz
12. Biological functions of methyl-CpG binding proteins
Pierre-Antoine Defossez and Irina Stancheva

Section V. DNA METHYLATION IN MEDICINE
13. Diseases associated with imprinting
J.F. Wilkins and F. Úbeda
14. DNA methylation changes in cancer
Minoru Toyota and Eiichiro Yamamoto
15. Epigenetic biomarkers
J. Tost
16. Distribution of methylation at the single-nucleotide level
E.

Über Autor(innen)

Xiaodong Cheng, Emory University School of Medicine, Atlanta, GA, USA and Robert M. Blumenthal, The University of Toledo College of Medicine, OH, USA