Translational Models of Parkinson's Disease and Related Movement Disorders

Erscheinungsjahr 2024
ISBN: 978-0-443-16128-5
Verlag: Elsevier Science

Buch, Englisch, 386 Seiten, Format (B × H): 217 mm x 276 mm, Gewicht: 1057 g

Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

Autoren/Hrsg.

Mohamed, Wael

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Section I. Understanding PD and related movement disorders 1. Neuroinflammation, glymphatic system, and Parkinson's disease 2. Pharmacotherapy of PD and related movements disorders and their limitations 3. Diagnosis and biomarkers of Parkinson's disease and related movement disorders 4. OMICS and bioinformatics in Parkinson disease and related movements disorders 5. Modeling Parkinson's disease with the alpha-synuclein protein 6. ?-Synuclein seeding assay and analysis Section II. Mammalian models of Parkinson's disease 7. SHH, nurr1, pitx3, and en1 models for Parkinson's disease 8. Stem cell for PD: Technical considerations 9. Deep brain stimulation using animal models of Parkinson's disease 10. The MitoPark mouse model of Parkinson's disease 11. The beta-sitosterol beta-D-glucoside (BSSG) rat model of Parkinson's disease Section III. Invertebrate models of Parkinson's disease 12. SCA1 zebrafish model 13. Various zebrafish models of Parkinson's disease: What gives us hope 14. Drosophila PD model 15. Caenorhabditis elegans models of tauopathy 16. LRRK2 in Caenorhabditis elegans model Section IV. Ethics and regulations related to translational PD models 17. Confounding factors for validation of PD models 18. Neurobehavioral characterization of PD models 19. Ethical regulations for induction and validation of PD models 20. The OMICS and PD models: Hopes or hypes 21. Parkinson's disease from an Ayurveda perspective: Opportunities and challenges for further research

Über Autor(innen)

Mohamed, Wael
Dr Mohamed is a Psychiatrist Neuroscientist. He earned his medical degree from Menoufia Medical School, Egypt and his research doctorate degree from the Penn State University, USA. After finishing his training in the neurosurgery department, he started his career as a clinical pharmacologist with psychopharmacology as a subspecialty. Currently, he is an assistant professor in IIUM, Malaysia as well as he is a doctorate student in cognitive psychology, IIUM, Malaysia. His translational brain research targets the investigation and development of novel treatment for AD and PD using rat, mice, and Zebra Fish animal models.