Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B

Erscheinungsjahr 2021
ISBN: 978-0-12-824143-1
Verlag: William Andrew Publishing

Buch, Englisch, 220 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 480 g

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more.

Zielgruppe

<p>Each volume of Progress in Molecular Biology and Translational Science will be useful for scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. Volumes also are appropriate for new investigators to a field who wish to familiarize themselves with the latest work.</p>

Autoren/Hrsg.

Weitere Mitwirkende

Teplow, David B.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Preface 

David Teplow 

1. Relevance of transgenic mouse models for Alzheimer's disease 

Leon Tai, Juan Maldonado Weng, Mary Jo LaDu and Scott Brady 

2. Mitochondrial transplant to replenish damaged mitochondria: A novel therapeutic strategy for neurodegenerative diseases?

Abhisek Mukherjee, Andrea D Becerra Calixto, Melissa Chavez, Jean Paul Delgado Charris and Claudio Soto 

3. Activity-dependent neuroprotective protein (ADNP)-end-binding protein (EB) interactions regulate microtubule dynamics toward protection against tauopathy 

Yanina Ivashko-Pachima and Illana Gozes 

4. Applying available knowledge and resources to alleviate familial and sporadic neurodegenerative disorders 

Mark P. Mattson 

5. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? 

Lawrence S.B. Goldstein and Utpal Das 

6. The search for novel targets in Alzheimer's disease-The 90s redux 

Christian Behl 

7. Adult hippocampal neurogenesis in Alzheimer's disease 

Ahmed Disouky and Orly Lazarov 

8. Early detection and personalized medicine: Future strategies against Alzheimer's disease 

Antonio Di Meco and Robert Vassar 

9. Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight 

Gianluigi Forloni, Pietro la Vitola, Milica Cerovic and Claudia Balducci

Über Autor(innen)

Teplow, David B.
David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson's disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Co-Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.