Metal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases

Erscheinungsjahr 2025
ISBN: 978-981-99-9402-1
Verlag: Springer Nature Singapore

Buch, Englisch, 125 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 230 g

Reihe: Springer Theses

In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.

Zielgruppe

Research

Autoren/Hrsg.

Mori, Keita

Fachgebiete

• Naturwissenschaften Chemie Anorganische Chemie
• Naturwissenschaften Chemie Chemie Allgemein
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff

Inhaltsverzeichnis

1. General introduction.- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases.- 3. Metal-dependent base pair switching of ,,-dicarboxymethyl-5-aminouracil nucleosides.- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases.- 5. Conclusion and perspectives.

Über Autor(innen)

Keita Mori received his B.Sc., M.Sc., and Ph.D. in chemistry from the School of Science, The University of Tokyo in 2018, 2020, and 2023, respectively, under supervision of Prof. Mitsuhiko Shionoya. In 2022, he joined Prof. Hanadi Sleiman's group at McGill University as a visiting researcher. He is now a JSPS postdoctoral fellow at Tokyo University of Agriculture and Technology (Prof. Takahiro Muraoka's group). His research interests focus on dynamic control of biomolecular structures and functions using synthetic molecules.