Therapeutic Applications of Quadruplex Nucleic Acids

Erscheinungsjahr 2016
ISBN: 978-0-12-810372-2
Verlag: William Andrew Publishing

Buch, Englisch, 208 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 430 g

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies.

Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics.

Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Zielgruppe

<p>Biochemists, chemists, professional researchers in laboratories in academic, government and corporate environments studying translational science, medicine and pharmacology, as well as, advanced undergraduate students, graduate students and medical students.</p>

Autoren/Hrsg.

Neidle, Stephen

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

1. Intro - history and milestones2. Fundamentals of DNA and RNA quadruplex structure and stability3. Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance4. Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents5. Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit6. Quadruplex ligands - chemistry and design - selectivity and assays7. Quadruplex ligands - basic biology and assays indirect and direct8. Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development9. Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding10. Future directions and conclusions

Über Autor(innen)

Neidle, Stephen
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.