Buch, Englisch, Band 68, 247 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 559 g
Buch, Englisch, Band 68, 247 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 559 g
Reihe: Advances in Biochemical Engineering/Biotechnology
ISBN: 978-3-540-67362-0
Verlag: Springer Berlin Heidelberg
Today, ergot alkaloids have found widespread clinical use and more than 50 formulations contain natural or semisynthetic ergot alkaloids. They are used in the treatment of uterine atonia, postpartum bleeding, migraine, orthostatic circulatory disturbances, senile cerebral insufficiency, hypertension, hyp- prolactinemia, acromegaly, and Parkinsonism. Recently, new therapeutic - plications have emerged, e.g., against schizophrenia and for therapeutic usage based on newly discovered antibacterial and cytostatic effects,immunomodu- tory and hypolipemic activity.The broad physiological effects of ergot alkaloids are based mostly on their interactions with neurotransmitter receptors on the cells. The presence of “hidden structures’’ resembling some important neu- humoral mediators (e.g., noradrenaline, serotonin, dopamine) in the molecules of ergot alkaloids could explain their interactions with these receptors [1]. Ergot alkaloids are produced by the filamentous fungi of the genus, Claviceps (e.g., Claviceps purpurea – Ergot, Mutterkorn). On the industrial scale these alkaloids were produced mostly by parasitic cultivation (field production of the ergot) till the end of the 1970s. Today this uneconomic method has been - placed by submerged fermentation. Even after a century of research on ergot alkaloids the search still continues for new, more potent and more selective ergot alkaloid derivatives.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Progress and Prospects of Ergot Alkaloid Research.- Antimicrobial Peptides of Lactic Acid Bacteria: Mode of Action, Genetics and Biosynthesis.- Biochemical Engineering Aspects of Solid State Bioprocessing.- Multistage Magnetic and Electrophoretic Extraction of Cells, Particles and Macromolecules.- Recovery of Proteins and Microorganisms from Cultivation Media by Foam Flotation.
