Nolan / Cazin Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 1

1. Auflage 2017
ISBN: 978-3-13-201321-6
Verlag: Thieme
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 548 Seiten, PDF

The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications.

Autoren/Hrsg.

Nolan, Steven

Cazin, Catherine

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse
• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

1.1 Introduction to N-Heterocyclic Carbenes1.1.1 Historic Perspectives on Carbenes1.1.2 Types of N-Heterocyclic Carbenes1.1.3 Synthesis of N-Heterocyclic Carbenes and Their Precursors1.1.4 Synthesis of N-Heterocyclic Carbene Complexes1.1.5 Quantifying Steric and Electronic Properties of N-Heterocyclic Carbenes1.2 Cross Coupling1.2.1 Suzuki–Miyaura Coupling1.2.2 Cross-Coupling Reactions Other Than Suzuki–Miyaura Coupling1.2.3 The Buchwald–Hartwig Reaction1.2.4 C—O, C—S, and C—B Bond Formation1.3 C—H Bond Functionalization1.4 Addition Reactions1.4.1 Hydrogenation1.4.2 Transfer Hydrogenation1.4.3 Hydrosilylation1.4.4 Catalytic Boron Addition Reactions1.4.5 Hydroamination1.4.6 Hydrothiolation, Hydroalkoxylation, and Hydroaryloxylation1.4.7 Hydration1.4.8 Hydroarylation1.4.9 Chloroacylation and Chloroalkoxycarbonylation of Alkynes1.4.10 Hydroformylation1.4.11 Hydroaminomethylation