Novel Approaches to Colorectal Cancer

Erscheinungsjahr 2021
ISBN: 978-0-12-824078-6
Verlag: William Andrew Publishing

Buch, Englisch, 484 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 910 g

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process.

Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality.

Zielgruppe

The volume will be of deep interest to physicians who treat and manage patients diagnosed with colorectal and other cancers, basic scientists, translational researchers, and clinicians. It will be beneficial to educators teaching undergraduate and graduate courses on cancer; corporate and private-sector entities developing new tools and strategies for preventing, detecting, and treating colorectal cancer; and to leaders in public health policy, including governmental, hospital-based, and the insurance industry, as they consider new strategies aimed at reducing the toll of the disease.

Autoren/Hrsg.

Weitere Mitwirkende

Berger, Franklin G.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Virologie

Inhaltsverzeichnis

1. Early age onset colorectal cancer
Swati G. Patel, Caitlin C. Murphy, Christopher H. Lieu, and Heather Hampel
2. Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma
Seth I. Felder, Jason B. Fleming, and Robert A. Gatenby
2. Early colorectal cancer detection-Current and evolving challenges in evidence, guidelines, policy, and practices
Robert A. Smith, Stacey Fedewa, and Rebecca Siegel
4. Personalized nutrition for colorectal cancer
Kai Wang and Mingyang Song
5. Immunotherapy in colorectal cancer
Parul Agarwal, Dung T. Le, and Patrick M. Boland
6. Racial and ethnic disparities in colorectal cancer incidence and mortality
John M. Carethers
7. Genomic and epigenomic biomarkers in colorectal cancer: From diagnosis to therapy
Juan Ruiz-Bañobre and Ajay Goel
8. Field carcinogenesis for risk stratification of colorectal cancer
Dionne Rebello, Elliott Rebello, Matthew Custodio, Xixi Xu, Sanil Gandhi, and Hemant K. Roy
9. Modeling colorectal cancers using multidimensional organoids
Ibrahim M. Sayed, Amer Ali Abd El-Hafeez, Priti P. Maity, Soumita Das, and Pradipta Ghosh
10. Unraveling the genomic landscape of colorectal cancer through mutational signatures
Marcos Díaz-Gay and Ludmil B. Alexandrov
11. Epigenetic alterations in the gastrointestinal tract: Current and emerging use for biomarkers of cancer
William M. Grady

Über Autor(innen)

Berger, Franklin G.
Dr. Berger is currently Director of Research & Outreach within the Colorectal Cancer Prevention Network at the University of South Carolina in Columbia, SC. He obtained a BA in Biology from the State University of NY at Buffalo in 1969, and a PhD in Biochemistry from Purdue University in 1974. In 1976. He began his career in cancer research at Roswell Park Cancer Institute in Buffalo, NY, where he was located until 1985 when he moved to the University of South Carolina. There, he was Professor in the Department of Biological Sciences until 2018, during which time he served as Department Chair (1996-2002) and was founding Director of the Center for Colon Cancer Research (2002-2018). For nearly 40 years, he ran a research laboratory focused on a variety of topics in mammalian molecular genetics, including colorectal cancer therapy and prevention. His efforts were generously supported by grants from the NIH, and resulted in over 130 articles in peer-reviewed scientific journals. Much of his research in colorectal cancer involved molecular mechanisms of resistance to chemotherapeutic agents.

Most recently, Dr. Berger has carried out investigations involving the efficacy of colorectal cancer screening in the community setting, and has been actively engaged in community outreach efforts directed at increasing colorectal cancer awareness and screening, particularly within uninsured and medically underserved populations throughout the State of South Carolina. With the support of grants from foundations, as well as federal and state agencies, he has led the design and implementation of education and evidence-based screening programs across the State. He recently guest-edited a special focus issue of the journal COLORECTAL CANCER (Future Science Group, publisher) dedicated to early-onset colorectal cancer.

Numerous graduate students and postdoctoral fellow trained in Dr. Berger's laboratory, and went on to academic and/or corporate careers in scientific research. Among Dr. Berger's awards for his efforts in the laboratory and the community are the SC Governor's Award in Science (2005), the Distinguished Service Award from the SC Gastroenterology Association (2009), election as a Fellow of the American Association for the Advancement of Science (2010), the Laurel Award in Cancer Prevention from the Prevent Cancer Foundation (2012), and a Commendation (Senate Bill S.1260) from the South Carolina General Assembly (2018).