Buch, Englisch, 581 Seiten, Paperback, Format (B × H): 152 mm x 229 mm, Gewicht: 857 g
ISBN: 978-1-4684-4366-0
Verlag: Springer US
The study of endotoxins has undergone cycles of enthusiastic research followed by neglect and revival again due to newly described biological effects attributed to endotoxins. It is almost a generally applicable rule that both extremes in such fluctuations in the popularity of certain re search fields are unjustified. It is obvious that exaggerated expectations will lead to disappointments, and complete neglect of a once-exciting field is to be followed by renewed attention, if the scientific basis of earlier interest was solid and remained so throughout. The healing ef fect of fever was praised as nature's blessed cure, until it was discov ered that it is caused by bacteria. When it became evident that by careful application one can arrive at therapeutic doses without intro ducing shock and hypotension, the era of fever therapy began. During this time, indiscriminate use of pyrogens was so widespread that the high expectations had to be followed by disillusionment. Since then, in terest in endotoxins experienced a few more oscillations, with varying wavelengths and amplitudes, the latest being triggered by the mitotic effect of endotoxin. This led to justified excitement among researchers who study the activation of the cells of the lymphatic system and the consequences thereof, including the release of important mediator mol ecules. Fever therapy is passe, but the healing that often followed the ap plication of endotoxins remains a well-documented fact.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
1. In Search of the Active Sites in Endotoxins.- 2. Effect of LPS on Carbohydrate and Lipid Metabolism.- 3. Effect of LPS on the Clotting System.- 4. Immunogenicity of Endotoxin.- 5. Protection against Gram-Negative Bacteremia with Antiserum to Endotoxins.- 6. The Radioprotective Effect of Bacterial Endotoxin.- 7. Induction of Endotoxin Tolerance.- 8. Effect of LPS on the Nonspecific Resistance to Bacterial Infections.- 9. Possibilities for Use of Endotoxin in Compromised Subjects.- 10. Stimulation of Nonspecific Resistance by Radiation-Detoxified Endotoxin.- 11. Lymphocyte Activation by Endotoxin and Endotoxin Protein: The Role of the C3H/HeJ Mouse.- 12. Adjuvant Action of Bacterial Endotoxins on Antibody Formation: A Historical Perspective.- 13. In Vitro Adjuvant Effect of Endotoxin: Review and Experiments.- 14. Stimulation of Immunomodulatory Factors by Bacterial Endotoxins and Nontoxic Polysaccharides.- 15. Interleukin 1: Release from LPS-Stimulated Mononuclear Phagocytes.- 16. Immunomodulatory Effects of Endotoxin.- 17. Lipopolysaccharide Regulation of the Immune Response: Beneficial Effects on Lymphoreticular Cells and a Model for Their Activation by LPS.- 18. The Role of Humoral Factors in Endotoxin-Induced Reactions.- 19. Induction of Interferon by Endotoxin.- 20. Endotoxin-Induced Release of Colony-Stimulating Factor.- 21. Colony-Stimulating Activity Induction in Patients with Acute Leukemia.- 22. Effect of Endotoxin on Graft-versus-Host Reactions.- 23. The Effect of Endotoxins on Skin and Kidney Transplantation Reactions.- 24. Adoptive Immunotherapy of Leukemia by Endotoxin-Induced Modulation of the Graft-versus-Host Reaction.- 25. Enhancement of Nonspecific Resistance to Tumor by Endotoxin.- 26. Induced Enhanced Resistance to Transplantable Tumors in Mice.- 27. Enhancement of Antitumor Resistance by Mycobacterial Products and Endotoxin.- 28. Role of LPS in Recognition and Induced Disease Resistance in Plant Hosts of Pseudomonas solanacearum.
