Pacak / Eisenhofer / Lenders Pheochromocytoma

Diagnosis, Localization, and Treatment
1. Auflage 2008
ISBN: 978-0-470-76638-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 184 Seiten, E-Book

Pheochromocytomas are rare but treacherous catecholamine-producingtumors, which if missed or not properly treated, will almostinvariably prove fatal. Prompt diagnosis is, therefore, essentialfor effective treatment, usually by surgical resection. Themanifestations are diverse and the tumor can mimic a variety ofconditions, often resulting in either erroneous diagnoses or adelayed diagnosis.
Reflecting the recent leaps in understanding this condition,Pheochromocytoma: Diagnosis, Localization, and Treatmentprovides a comprehensive update on the improvements in thediagnosis, localization, management and treatment ofpheochromocytomas - providing you with the latest cuttingedge science alongside best clinical practice. Written by theleading names in the field, the text details the significantdevelopments in understanding the genetics and biology of thetumors, coupled with technological advances in the fields ofanalytical chemistry, genomics, molecular biology and nuclearmedicine.
The most comprehensive book on pheochromocytoma
* * Provides cutting edge science and clinical guidance
* Written by the leading names in the field
* Authors present their recently developed novel biochemical testfor the diagnosis of Pheochromocytoma

Autoren/Hrsg.

Pacak, Karel

Eisenhofer, Graeme

Lenders, Jacques

Inhaltsverzeichnis

1 Introduction.
2 Historical comments.
3 Pathology.
4 Clinical presentation of pheochromocytoma.
4.1 Signs and Symptoms.
4.2 Differential Diagnosis.
4.3 Special Presentations.
4.3.1 Diagnosis of Pheochromocytoma in Patients with anIncidentally Discovered Adrenal Mass.
4.3.2 Pheochromocytoma as an Endocrine Emergency.
4.3.2.1 Hypertensive Crisis.
4.3.2.2 Hypotension and Shock.
4.3.2.3 Multisystem Failure.
4.3.2.4 Cardiac Emergencies.
4.3.2.5 Acute Peripheral Ischemia.
4.3.2.6 Pulmonary Emergencies.
4.3.2.7 Gastrointestinal Emergencies.
4.3.2.8 Nephrological Emergencies.
4.3.2.9 Neurological Emergencies.
4.3.3 Malignant Pheochromocytoma.
4.3.4 Pheochromocytoma in Children.
4.3.5 Pheochromocytoma in Pregnancy.
4.3.6 Pseudopheochromocytoma.
4.3.7 Factitious Pheochromocytoma.
5 Current trends in genetics of pheochromocytoma.
5.1 MEN Syndromes.
5.1.1 Diagnostic Approaches.
5.2 VHL Syndrome.
5.3 NF Type 1.
5.4 Succinate Dehydrogenase Gene Related Pheochromocytoma.
5.5 Genetic Problems in Sporadic and OtherPheochromocytomas.
6 Catecholamines and adrenergic receptors.
6.1 Synthesis and Sources of Catecholamines.
6.2 Synthesis of Catecholamines in Pheochromocytoma.
6.3 Storage and Release of Catecholamines by the SympathoadrenalSystem.
6.4 Uptake and Metabolism of Catecholamines Produced by theSympathoadrenal System.
6.5 Catecholamine Metabolism in Hepatomesenteric Organs.
6.6 Catecholamines Metabolism and Release byPheochromocytoma.
6.7 Kinetics and Elimination of Catecholamines and TheirMetabolites.
6.8 Pharmacology of Catecholamine Systems: Implications forPheochromocytoma.
6.9 Physiology of Catecholamine Systems.
6.9.1 Adrenal Medullary Hormone System.
6.9.2 Peripheral Dopamine Systems.
6.10 Adrenergic Receptors and Their Functions.
6.11 Actions of the Catecholamines.
7 Current trends in biochemical diagnosis ofpheochromocytoma.
7.1 Biochemical Tests of Catecholamine Excess.
7.2 Measurement Methods.
7.3 Reference Intervals.
7.4 Initial Biochemical Testing.
7.5 Follow-up Biochemical Testing.
7.6 Collection and Storage of Plasma and Urine Specimens.
7.7 Interferences from Diet and Drugs.
7.8 Pharmacologic Tests.
7.9 Additional Interpretative Considerations.
7.10 Summary.
8 Current trends in localization of pheochromocytoma.
8.1 Anatomical Imaging of Pheochromocytoma.
8.1.1 Computed Tomography.
8.1.2 Magnetic Resonance Imaging.
8.2 Functional Imaging of Pheochromocytoma.
8.2.1 MIBG Scintigraphy.
8.2.2 Positron Emission Tomography.
8.2.3 Somatostatin Receptor Scintigraphy (Octreoscan).
8.2.4 Current Imaging Algorithm.
9 Treatment of pheochromocytoma.
9.1 Medical Therapy and Preparation for Surgery.
9.2 Postoperative Management.
10 Future trends and perspectives.
10.1 Genomics in Pheochromocytoma Research.
10.2 Proteomics in Pheochromocytoma Research.
10.3 Future Therapeutic Modalities for Pheochromocytoma.
References.
Index

Über Autor(innen)

Professor Karel Pacak put together the PheochromocytomaResearch Program at the NIH, one of the most prestigious andlargest programs world-wide; published over 80 articles/bookchapters on this topic. Introduced new biochemical and imagingapproaches to this tumor, especially the use of 18F-fluorodopaminein localization of pheochromocytoma. He also developed newbiochemical and imaging algorithms for pheochromocytoma forpracticing physicians. Moreover, developed new animal model ofmetastatic pheochromocytoma. Currently working as the Chief ofSection on Medical Neuroendocrinology, NICHD. He is also Professorof Medicine at Georgetown University, Washington DC and CharlesUniversity, Prague, Czech Republic.
Dr. Eisenhofer is a clinical biochemist with broadexperience in basic and patient-oriented research on neuroedocrineand autonomic nervous system function in health and disease.Relevant achievements include codevelopment with Dr. JacquesLenders of the first HPLC method for measurements of plasma freemetanephrines, a test now used for improved biochemical diagnosisof pheochromocytoma. Dr. Eisenhofer was also responsible forinitial development of 18F-fluorodopamine as a positron emissiontomographic imaging agent for visualizing sympathetic nerves andneuroendocrine tumors. Dr. Eisenhofer co-chairs thePheochromocytoma RESsearch Support ORganization (PRESSOR -http://www.pressor.org).
Professor Jacques Lenders did his medical study at theUniversity of Nijmegen, the Netherlands. In 1982 he finished histraining for internist and in 1988 he defended his thesis on'Blood pressure and catecholamines in essentialhypertension'. From august 1991 till january 1993 he was'visiting associate' at the 'ClinicalNeuroscience Branch' of the 'National Institute ofNeurological Disorders and Stroke' (National Institutes ofHealth', Bethesda, USA). In 2005 he was appointed asprofessor of Vascular Medicine at the University Medical Center inNijmegen, The Netherlands. He is deputy-chairman of the Departmentof General Internal Medicine.