Pancreatic Cancer: Basic Mechanisms and Therapies

Erscheinungsjahr 2023
ISBN: 978-0-443-13354-1
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Pancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research.

Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC.

In this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research.

Autoren/Hrsg.

Weitere Mitwirkende

Emdad, Luni

Atfi, Azeddine

Gogna, Rajan

Trevino, Jose G

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

1. Notch signaling pathway in pancreatic tumorigenesis
Keli Xu
2. EMT in Pancreatic Ductal Adenocarcinoma
Azeddine Atfi
3. Review of Immunocompetent In-vivo Models of PDAC  OR Stromal Microenvironment Impact on Pacreatic Cancer Progression and Metastasis
Vignesh Vudatha and Jose Trevino
4. Interplay between MAP Kinases and tumor microenvironment: Opportunity for immunotherapy in pancreatic cancer
Ajay Rana and Kumar Sandeep
5. KRAS in pancreatic cancer: Emerging therapeutic strategies
Daohong Zhou
6. Disparities in Pancreatic Cancer Clinical Trials
Allison Neal Martin and Rebecca A. Snyder
7. Tumor heterogeneity: an oncogenic driver of PDAC progression and therapy resistance under stress conditions
Esha Madan
8. Oncogenic Signaling Pathways in Pancreatic Ductal Adenocarcinoma
Kedar Nath Natarajan
9. Chemoresistance in Pancreatic Ductal Adenocarcinoma: Overcoming Resistance to Therapy
Praveen Bhoopathi
10. Tumor microenvironment interactions with cancer stem cells in pancreatic ductal adenocarcinoma
Rajan Gogna

Über Autor(innen)

Trevino, Jose G
Dr. Jose Trevino is an associate professor at the Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA.

Atfi, Azeddine
Dr. Azeddine Atfi is the leader of Cancer Biology Program at NCI-designated Massey Cancer Center. He is also the Professor and Chair of
the Cellular and Molecular Pathogenesis Division at the Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.

Gogna, Rajan
Dr. Rajan Gogna is an assistant professor at the School of Medicine Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.

Emdad, Luni
Luni Emdad, PhD, MBBS received her PhD degree in Medical Science from the Nagoya University Graduate School of Medicine and her Bachelor degree in Medicine and Surgery (MBBS) from Dhaka Medical college. After completing her Postdoctoral training in the department of Pathology and Urology with Dr. Paul B. Fisher at the Columbia University, she remained as Associate Research Scientist at the Columbia University until Dec 2007. From 2008-2011, she served as Assistant Professor, Department of Neurosurgery, Mount Sinai School of Medicine, New York. In 2011, she joined the Department of Human and Molecular Genetics, Virginia Commonwealth University as an Assistant professor. In 2020, she was promoted to Associate professor at Virginia Commonwealth University. Dr. Emdad is a scientist with a clinical background (dual degree of Bachelors of Medicine and Surgery and Ph.D.) and has a longstanding research experience in cancer research with in depth molecular knowledge in targeted experimental therapeutics development for cancer.

She has published over 150 in journals such as Proceedings of the National Academy of Science USA, Cancer Research, Journal of Clinical Investigation, Hepatology, Oncogene, Semin Cancer Biol, Neuro-Oncology and so on. She has served as principal investigator in two sponsored research programs and an inventor in two issued US patents.