Models and Mechanisms
Buch, Englisch, 679 Seiten, Paperback, Format (B × H): 178 mm x 254 mm, Gewicht: 1286 g
ISBN: 978-1-4757-9642-1
Verlag: Springer US
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Section I Xenobiotics: Metabolism and Interaction with Cellular Macromolecules.- Section II Developmental Stages of Carcinogenesis.- Section III Regulation of Cell Growth in Chemical Carcinogenesis.- Section IV Nutritional Carcinogenesis and Anticarcinogenesis.- Section V Mechanisms in Human Carcinogeneis.
