Green Chemistry Strategies for Drug Discovery

Erscheinungsjahr 2015
ISBN: 978-1-84973-961-0
Verlag: RSC Publishing

Buch, Englisch, 347 Seiten, Format (B × H): 160 mm x 239 mm, Gewicht: 635 g

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate.

Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment.
The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included.

This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Autoren/Hrsg.

Peterson, Emily A

Manley, Julie B

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Toxikologie, Gefahrstoffe, Sicherheit in der Chemie
• Naturwissenschaften Chemie Analytische Chemie Umweltchemie, Lebensmittelchemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Introduction: The Five Ws of Pharmaceutical Green Chemistry;

Barriers to Adopting Green Chemistry in Drug Discovery;

Toward a Green Laboratory: One Reaction at a Time;

Greener Solvent Usage for;

Discovery Chemistry Analysis and Purification;

Green Chemistry and High Throughput Screening;

Continuous Processing in Drug Discovery;

Applying Green Chemistry Principles in Biologics Drug Development;

Recycling and Reuse in the Laboratory;

The Need for a Green Electronic Lab Notebook;

Toxicology for Chemical Safety and Sustainability;

Environmental Regulations and the Green Chemist;

Patent Protection and Green Chemistry Innovation;

The Business Case for Green Chemistry in Drug Discovery

Über Autor(innen)

Emily A. Peterson is a Senior Scientist in Medicinal Chemistry at Amgen. Emily received her Ph. D. in Organic Chemistry from University of California–Irvine with Larry E. Overman, accomplishing the total synthesis of biologically interesting alkaloid natural products and their analogues. She then conducted postdoctoral studies in asymmetric organocatalysis at Harvard University in the labs of Eric N. Jacobsen. Her research in Medicinal Chemistry has been primarily in the areas of oncology, schizophrenia and neuropathic pain. In addition to her drug discovery efforts, she has led the Green Chemistry Team at the Amgen Cambridge Site since 2009 and is a member of the American Chemical Society’s Green Chemistry Institute Medicinal Chemistry Round Table.