Pramanik / Chen / Lee Characterization of Impurities and Degradants Using Mass Spectrometry

1. Auflage 2011
ISBN: 978-0-470-92136-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 496 Seiten, E-Book

Reihe: Wiley Series on Pharmaceutical Science

The book highlights the current practices and future trends instructural characterization of impurities and degradants. It beginswith an overview of mass spectrometry techniques as related to theanalysis of impurities and degradants, followed by studiesinvolving characterization of process related impurities (includingpotential genotoxic impurities), and excipient related impuritiesin formulated products. Both general practitioners inpharmaceutical research and specialists in analytical chemistryfield will benefit from this book that will detail step-by-stepapproaches and new strategies to solve challenging problems relatedto pharmaceutical research.

Autoren/Hrsg.

Chen, Guodong

Pramanik, Birendra

Lee, Mike S.

Über Autor(innen)

BIRENDRA N. PRAMANIK is a Distinguished Fellow at MerckResearch Laboratories, where he directs spectroscopy programscovering mass spectrometry and NMR efforts. He was previously adistinguished fellow at Schering-Plough Research Institute. Hereceived his PhD in organic chemistry under the late Professor AjayK. Bose from Stevens Institute of Technology in 1977.
MIKE S. LEE is President of Milestone DevelopmentServices, a provider of consulting services specializing inpharmaceutical analysis and accelerated drug discovery anddevelopment strategies in Newtown, Pennsylvania. He previouslydirected program research at Bristol-Myers Squibb, PharmaceuticalResearch Institute in New Brunswick, New Jersey.
GUODONG CHEN is Principal Scientist in Bioanalytical andDiscovery Analytical Sciences at Bristol-Myers Squibb in Princeton,New Jersey. He heads a mass spectrometry group in support of drugdiscovery as well as development programs in small moleculepharmaceuticals and biologics. He received his PhD in analyticalchemistry from Purdue University under the direction of ProfessorR. Graham Cooks.