Prochazka / Procházka Surface-Enhanced Raman Spectroscopy

Bioanalytical, Biomolecular and Medical Applications
1. Auflage 2016
ISBN: 978-3-319-23992-7
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 221 Seiten, eBook

Reihe: Biological and Medical Physics, Biomedical Engineering

This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.

Zielgruppe

Research

Autoren/Hrsg.

Prochazka, Marek

Procházka, Marek

Inhaltsverzeichnis

Introduction.- Basics of Raman scattering (RS) spectroscopy.- Basics of surface-enhanced Raman scattering (SERS).- Bioanalytical SERS applications.- Biomolecular SERS applications.- SERS investigations of cells, viruses and microorganisms.- Medical applications of SERS.- Conclusions and outlook.