Protein Engineering for Therapeutics, Part B

Erscheinungsjahr 2012
ISBN: 978-0-12-396962-0
Verlag: William Andrew Publishing

Buch, Englisch, 392 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 770 g

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds

Zielgruppe

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Autoren/Hrsg.

Weitere Mitwirkende

Wittrup, K. Dane

Verdine, Gregory L.

Fachgebiete

• Naturwissenschaften Chemie Analytische Chemie
• Naturwissenschaften Biowissenschaften Enzymologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Part III: Peptides
1. Stapled Peptides for Intracellular Drug Targets
2. Mapping of vascular zip codes by phage display
3. Engineering cyclic peptide toxins
4. Peptide Discovery using Bacterial Display and Flow Cytometry

Part V: Scaffolds
5. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
6. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
7. Anticalins: small engineered binding proteins based on the lipocalin scaffold
8. T Cell Receptor Engineering
9. Engineering Knottins as Novel Binding Agents

Part VI: Pharmacokinetics
10. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
11. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
12. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells