Protein Structure and Diseases

Erscheinungsjahr 2011
ISBN: 978-0-12-381262-9
Verlag: William Andrew Publishing

Buch, Englisch, 312 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 660 g

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Zielgruppe

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Autoren/Hrsg.

Weitere Mitwirkende

Donev, Rossen

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

- Graphical representation and mathematical characterization of protein sequences and applications to viral proteinsAmbarnil Ghosh and Ashesh Nandy

- Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyriaArola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet

- Role of Fibrin Structure in Thrombosis and Vascular DiseaseAmy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns

- Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational ViewAnton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov

- Proteins MOVE! Protein dynamics and long-range allostery in cell signalingZimei Bu and David J. E. Callaway

- Structural diversity of class I MHC like molecules and its implications in binding specificitiesMd. Imtaiyaz Hassan and Faizan Ahmad

Über Autor(innen)

Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.