Rainsford Aspirin and the Salicylates

1. Auflage 2013
ISBN: 978-1-4831-9199-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 358 Seiten, Web PDF

Aspirin and the Salicylates focuses principally on aspirin. Topics ranging from analytical chemistry and pediatric medicine, taxonomy and cartels, enzymology and toxicity, to renal functions and rheumatology are also included in this compilation. This book emphasizes that salicylates are polycompetent drugs that influence a large number and variety of biological processes. Their multifactorial actions, in relation to the known therapeutic and toxic effects are clearly described. This text likewise provides a refreshing multidisciplinary approach to aspirins that cover the whole extent from chemical to clinical aspects. This publication is a good reference for clinicians, pharmacists, and students intending to acquire general knowledge of the aspirin and salicylates.

Autoren/Hrsg.

Rainsford, K. D.

Inhaltsverzeichnis

1;Front Cover;1
2;Aspirin and the Salicylates;6
3;Copyright Page;7
4;Table of Contents;18
5;Foreword 1;8
6;Foreword 2;10
7;Preface;12
8;Abbreviations and Nomenclature;14
9;Chapter 1. History and Development of the Salicylatess;26
9.1;Early use of salicylate-containing plants;26
9.2;Chemical developments;28
9.3;References;36
10;Chapter 2. Occurrence, Properties and Synthetic Developments of the Salicylates;38
10.1;Naturally occurring salicylates;38
10.2;Commercial synthesis and properties of the salicylates;40
10.3;Experimental drugs;45
10.4;Conclusions;53
10.5;References;53
11;Chapter 3. Absorption, Metabolism and Disposition of the Salicylates;57
11.1;Introduction;57
11.2;Absorption, Metabolism and Distribution;57
11.3;Analytical Methods;81
11.4;References;83
12;Chapter 4. Pharmacological and Biochemical Actions of the Salicylates 6;92
12.1;Introduction;92
12.2;Anti-inflammatory effects;94
12.3;Analgesic activity;148
12.4;Anti-pyresis;155
12.5;References;156
13;Chapter 5. Side-Effects and Toxicology of the Salicylates;173
13.1;Introduction;173
13.2;Gastrointestinal side-effects;176
13.3;Nephropathy;246
13.4;Hepatotoxicity;258
13.5;Hypersensitivity reactions and asthma;261
13.6;Teratogenesis and pregnancy;266
13.7;Miscellaneous side-effects;268
13.8;Acute salicylate poisoning;270
13.9;Conclusions;274
13.10;References;275
14;Chapter 6. Therapeutic Uses of the Salicylates;297
14.1;Introduction ;297
14.2;Arthritic conditions;298
14.3;Analgesia ;309
14.4;Anti-pyresis ;314
14.5;Thromboembolic conditions ;315
14.6;Perturbed metabolic states ;318
14.7;Other possible uses ;322
14.8;References;327
15;Index;338