Recent Advances in Targeting Inflammation

Ion Channels, Gpcr Signaling Tools, Therapies, and Beyond
Erscheinungsjahr 2025
ISBN: 978-0-443-33887-8
Verlag: Elsevier Science

Buch, Englisch, 600 Seiten, Format (B × H): 191 mm x 235 mm

Recent Advances in Targeting Inflammation: Ion Channels, GPCR Signaling Tools, Therapies, and Beyond delves into the multifaceted occurrences of inflammation across different systems, such as neuroinflammation and gastric inflammation. The book's main goal is to present the latest highlights, covering advancements in inflammation, investigational therapies, animal models, and biomarkers. These insights are crucial for better diagnosis, monitoring, and potential therapeutic options for patients suffering from both acute and chronic inflammation. This comprehensive work explores various topics, including ion channel regulation in inflammation, GPCR regulation, signaling pathways, and therapeutic approaches.

It emphasizes the importance of understanding the role of ion channels, GPCR, and nutrition in managing inflammation effectively. Additionally, the book discusses the global impact of chronic inflammation on health outcomes, stressing the need for improved healthcare planning and strategies.

Autoren/Hrsg.

Rajagopal, Senthilkumar

Sethi, Gautam

Ramkumar, Kunka Mohanram

Chatterjee, Ankita

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

Section 1: Introduction
1. Introduction: Voltage gated ion channels and GPCR signaling in inflammation
2. Calcium - dependent regulation of ion channels in inflammation
3. Role of GPCR signaling in Neuroinflammation

Section 2: Ion channels regulation in inflammation
4. Unveiling the Significance of Mitochondrial Ion Channels in Inflammatory Responses
5. Neuroinflammation with regards to ion Channels dysregulation

Section 3: GPCR regulation in inflammation
6. Role of GPCRs in Inflammasome activation and Therapeutics
7. GPCR modulated inflammatory responses in liver: A transitional move from NAFLD to NASH
8. Molecularity of GPCR Signaling involved in Neuroinflammation
9. GPCR regulation of chemokine, lipid mediator and neuropeptide receptors in inflammation

Section 4: Signaling Pathways in Inflammation
10. G protein-coupled receptors: structure- and function-based drug discovery
11. Alteration of inflammatory Signaling network in cancer
12. Role of MAPK in Neuroinflammation: A molecular approach

Section 5: Therapeutic approaches for inflammation
13. G-protein-coupled receptors (GPCRs) in the treatment of diabetes
14. Application of Nanoparticles for Targeting G Protein-Coupled Receptors
15. Therapeutic approaches for inflammation
16. Nano-therapeutic strategies for inflammation via GPCR modulation: An update
17. Innovative GPCR Targeting Strategies in Drug Therapy for Inflammatory Diseases: Mechanistic Approaches
18. Distinctive application of nano-therapeutics in mitigating inflammation
19. Therapies targeting ion channels and GPCRs

Über Autor(innen)

Chatterjee, Ankita
Dr. Ankita Chatterjee is an Assistant Professor in Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, India. Her research area includes microbial technology focusing on the effect of microorganisms and microbial metabolites in reducing the environmental pollutants. The area of research also spans around extraction of pharmaceutically active bioactive compounds from natural sources and their analyses. She has 35 publications at present which include 22 research and review papers in reputed international and national journals as well as 13 book chapters in internationally edited books under reputed publishers. She has served as reviewer for various international journals.

Sethi, Gautam
Dr. Gautam Sethi is a tenured Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism(s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted several publications in high impact factor peer reviewed journals and many international awards. He also serves as an editorial board member for over more than 15 international journals